Application in Pharmaceutical Sciences Research Group (APRES)

1. Introduction

In modern life, the trend “Return to natural” becomes popular, and the use of natural products increase sharply in recent years. As a result, studies on natural products attract the interest of scientists all over the world.

Vietnam is a tropical country with a hot and humid climate, which is an excellent source of potential natural products for the treatment. The APRES group was established to exploit the strength of natural products in Vietnam applied for therapy and promote the value of these products in the global market. APRES brought together scientists and lecturers who have a particular interest in Vietnamese herbal research.

2. Mission and Vision

Our vision is to build APRES as a leading research group into natural products that promote Vietnamese medicinal plants’ pharmaceutical value.

Our mission is to cooperate with the local governments to discover the medicinal plant in these areas and establish products from these herbs. These products contribute to increase the reputation of Vietnamese natural products and enhance the income of local governments as well as Ton Duc Thang University.

3. Research topics

Discover bioactive compounds from Vietnamese natural products, isolate pure compounds to be used as the reference standards for quality control and bioactivity evaluation.

Develop modern preparation of natural products, transfer to the manufacturer to establish high-quality drugs and functional foods for local and global consumption.

4. Current members

TS. Nguyễn Trường Huy

 

Dr. Nguyễn Trường Huy

Positions: Headof APRES

Areas of expertise: Drug quality control, Natural products

Email: nguyentruonghuy@tdtu.edu.vn

Research track record:

  • ISI papers: 6
  • Total ISI Citations: 99
  • ISI H-index: 5
  • At most 5 top journals:
  1. Huy Truong Nguyen, Dong-Kyu Lee, Young-Geun Choi, Jung-Eun Min, Sang Jun Yoon, Yun-Hyun Yu, Johan Lim, Jeongmi Lee, Sung Won Kwon, Jeong Hill Park. “A 1H NMR-based metabolomics approach to evaluate the geographical authenticity of herbal medicine and its application in building a model effectively assessing the mixing proportion of intentional admixtures: A case study of Panax ginseng”, Journal of Pharmaceutical and Biomedical Analysis, 124(120-28), 2016
  2. Huy Truong Nguyen, Dong-Kyu Lee, Won Jun Lee, GwangJin Lee, Sang Jun Yoon, Byong-kyu Shin, Minh Duc Nguyen, Jeong Hill Park, Jeongmi Lee, Sung Won Kwon. “UPLC-QTOFMS based metabolomics followed by stepwise partial least square-discriminant analysis (PLS-DA) explore the possible relation between the variations in secondary metabolites and the phylogenetic divergences of the genus Panax”, Journal of Chromatography B, 1012(61-68), 2016.
  3. Huy Truong Nguyen, Jung-Eun Min, Nguyen Phuoc Long, Ma Chi Thanh, Thi Hong Van Le, Jeongmi Lee, Jeong Hill Park, Sung Won Kwon. “Multi-platform metabolomics and a genetic approach support the authentication of agarwood produced by Aquilaria crassna and Aquilaria malaccensis”, Journal of Pharmaceutical and Biomedical Analysis, 142 (136-144), 2017.
  4. Huong Thuy Le, Huy Truong Nguyen, Hye-Young Min, Seung Yeob Hyun, Soonbum Kwon, Yeongcheol Lee, Thi Hong Van Le, Jeeyeon Lee, Jeong Hill Park, Ho-Young Lee. “Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells”, Cancer Letters, 412(297-307), 2018.
  5. Kim Long Vu-Huynh, Huy Truong Nguyen, Thi Hong Van Le, Chi Thanh Ma, Gwang Jin Lee, Sung Won Kwon, Jeong Hill Park, Minh Duc Nguyen. “Accumulation of Saponins in Underground Parts of Panax vietnamensis at Different Ages Analyzed by HPLC-UV/ELSD”, Molecules, 25(13), 3086, 2020.
Prof. Đức

Prof. Dr. Nguyễn Minh Đức

Positions: Member of APRES

Areas of expertise: Natural product isolation, quality control of herbal drugs, products development

Email: nguyenminhduc@tdtu.edu.vn

Research track record:

  • ISI papers: 34
  • Total ISI Citations: 907
  • ISI H-index: 19

• At most 5 top journals:

  1. Vu-Huynh, Kim Long, Huy Truong Nguyen, Thi Hong Van Le, Chi Thanh Ma, Gwang Jin Lee, Sung Won Kwon, Jeong Hill Park, and Minh Duc Nguyen. "Accumulation of Saponins in Underground Parts of Panax vietnamensis at Different Ages Analyzed by HPLC-UV/ELSD." Molecules 25, no. 13 (2020): 3086.
  2. Vu-Huynh, Kim Long, Thi Hong Van Le, Huy Truong Nguyen, Hyung Min Kim, Ki Sung Kang, Jeong Hill Park, and Minh Duc Nguyen. "Increase in Protective Effect of Panax vietnamensis by Heat Processing on Cisplatin-Induced Kidney Cell Toxicity." Molecules 24, no. 24 (2019): 4627.
  3. Duc, Nguyen Minh, Nguyen Thoi Nham, Ryoji Kasai, Aiko Ito, Kazuo Yamasaki, and Osamu Tanaka. "Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. I." Chemical and pharmaceutical bulletin 41, no. 11 (1993): 2010-2014.
  4. Duc, Nguyen Minh, Ryoji KASAI, Kazuhiro OHTANI, Aiko ITO, Nguyen THOI NHAM, Kazuo YAMASAKI, and Osamu TANAKA. "Saponins from Vietnamese ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II." Chemical and pharmaceutical bulletin 42, no. 1 (1994): 115-122.
  5. NGUYEN, Minh Duc, Ryoji KASAI, Kazuhiro OHTANI, Aiko ITO, Thoi Nham NGUYEN, Kazuo YAMASAKI, and Osamu TANAKA. "Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III." Chemical and Pharmaceutical Bulletin 42, no. 3 (1994): 634-640.
TS. Điền

Dr. Phạm Phước Điền

Positions: Member of APRES

Areas of expertise: Organic chemistry

Email: phamphuocdien@tdtu.edu.vn

Research track record:

  • ISI papers: 22
  • Total ISI Citations: 145
  • ISI H-index: 7
  • At most 5 top journals:
  1. Pham, Phuoc Dien, Sophie Monge, Vincent Lapinte, Yann Raoul, and Jean Jacques Robin. "Various radical polymerizations of glycerol‐based monomers." European Journal of Lipid Science and Technology 115, no. 1 (2013): 28-40.
  2. Pham, Phuoc Dien, Philippe Bertus, and Stephanie Legoupy. "Solvent-free direct reductive amination by catalytic use of an organotin reagent incorporated on an ionic liquid." Chemical Communications 41 (2009): 6207-6209.
  3. Louaisil, Nicolas, Phuoc Pham, Fabien Boeda, Djibril Faye, Anne-Sophie Castanet, and Stéphanie Legoupy. "Ionic liquid supported organotin reagents: green tools for Stille cross-coupling reactions with brominated substrates." European Journal of Organic Chemistry 2011 (2011): 143-149.
  4. Pham, Phuoc Dien, Vincent Lapinte, Yann Raoul, and Jean‐Jacques Robin. "Lipidic polyols using thiol‐ene/yne strategy for crosslinked polyurethanes." Journal of Polymer Science Part A: Polymer Chemistry 52, no. 11 (2014): 1597-1606.
  5. Dien Pham, Phuoc, Jürgen Vitz, Cécile Chamignon, Arnaud Martel, and Stéphanie Legoupy. "Stille Cross‐Coupling Reactions with Tin Reagents Supported on Ionic Liquids." European Journal of Organic Chemistry 2009, no. 19 (2009): 3249-3257.
TS. Hiệp

 

Dr. Nguyễn Đình Hiệp

Positions: Member of APRES

Areas of expertise: Natural products, Pharmaceutical chemistry, Polymer

Email: nguyendinhhiep@tdtu.edu.vn

Research track record:

  • ISI papers: 6
  • Total ISI Citations: 99
  • ISI H-index: 5
  • At most 5 top journals:
  1. Trinh, Binh TD, Hiep D. Nguyen, Hieu T. Nguyen, Phuoc D. Pham, Ngoc TN Ngo, Le-Thu T. Nguyen, Ly TT Nguyen, Dzung N. Bui, Son V. Dang, and Lien-Hoa D. Nguyen. "Cytotoxic limonoids from the bark of Walsura cochinchinensis." Fitoterapia 133 (2019): 75-79.
  2. Nguyen, T. M. T., H. D. Nguyen, L. T. T. Nguyen, and N. T. Doan. "Students’ employment of highorder thinking skills in English Linguistics Courses: A case study at VNU-ULIS." In Proceedings of an ELT conference on innovative English language teaching for provincial universities, pp. 215-220. 2015.
  3. Bui, Danh A., Minh K. Vu, Hiep D. Nguyen, Le-Thu T. Nguyen, Son V. Dang, and Lien-Hoa D. Nguyen. "A protostane and two lanostanes from the bark of Garcinia ferrea." Phytochemistry Letters 10 (2014): 123-126.
  4. Nguyen, Hiep D., Binh TD Trinh, and Lien-Hoa D. Nguyen. "Guttiferones QS, cytotoxic polyisoprenylated benzophenones from the pericarp of Garcinia cochinchinensis." Phytochemistry letters 4, no. 2 (2011): 129-133.
  5. Nguyen, Hiep D., Binh TD Trinh, Nam K. Nguyen, Son V. Dang, Hung D. Pham, and Lien-Hoa D. Nguyen. "Xanthones from the twigs of Cratoxylum cochinchinense." Phytochemistry Letters 4, no. 1 (2011): 48-51.
TS. Hiền

 

Dr. Nguyễn Minh Hiền

Positions: Member of APRES

Areas of expertise: Natural products chemistry

Email: nguyenminhhien@tdtu.edu.vn

Research track record:

  • ISI papers: 13
  • Total ISI Citations: 78
  • ISI H-index: 06
  • At most 5 top journals:
  1. Minh Nguyen, Hien, Huy Truong Nguyen, Nwet Win, Chin Piow Wong, Kim Long Vu Huynh, Nhat Nam Hoang, Kiep Minh Do et al. "Antimelanogenic Activity of Ocotillol‐Type Saponins from Panax vietnamensis." Chemistry & Biodiversity 17, no. 5 (2020): e2000037.
  2. Nguyen, Hien Minh, Takuya Ito, Nwet Nwet Win, Hung Quoc Vo, Hoai Thi Nguyen, and Hiroyuki Morita. "A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities." Natural product research 33, no. 8 (2019): 1175-1181.
  3. Ito, Takuya, Hien Minh Nguyen, Nwet Nwet Win, Hung Quoc Vo, Hoai Thi Nguyen, and Hiroyuki Morita. "Three new sesquiterpene aminoquinones from a Vietnamese Spongia sp. and their biological activities." Journal of natural medicines 72, no. 1 (2018): 298-303.
  4. Nguyen, Hien Minh, Takuya Ito, Shin-ichiro Kurimoto, Mika Ogawa, Nwet Nwet Win, Vo Quoc Hung, Hoai Thi Nguyen, Takaaki Kubota, Jun'ichi Kobayashi, and Hiroyuki Morita. "New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities." Bioorganic & Medicinal Chemistry Letters 27, no. 14 (2017): 3043-3047.
  5. Nguyen, Hien Minh, Takuya Ito, Nwet Nwet Win, Takeshi Kodama, Vo Quoc Hung, Hoai Thi Nguyen, and Hiroyuki Morita. "New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp." Phytochemistry Letters 17 (2016): 288-292.
TS.Ý

 

Dr. Vũ Thiên Ý

Positions: Member of APRES

Areas of expertise: Organic Chemistry

Email: vuthieny@tdtu.edu.vn

Research track record:

  • ISI papers: 7
  • Total ISI Citations: 28
  • ISI H-index: 3
  • At most 5 top journals:
  1. Mai, Nguyen Thi, Ngo Thi Lan, Thien Y. Vu, Phuong Thi Mai Duong, Nguyen Thanh Tung, and Huong Thi Thu Phung. "Estimation of the ligand-binding free energy of checkpoint kinase 1 via non-equilibrium MD simulations." Journal of Molecular Graphics and Modelling 100 (2020): 107648.
  2. Nguyen, Ha Thi, Thien-Y. Vu, Vishala Chandi, Haritha Polimati, and Vinay Bharadwaj Tatipamula. "Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites." Scientific reports 10, no. 1 (2020): 1-10.
  3. Thi, L. L. D., P. N. K. Tuyen, and Thien Y. Vu. "Flower-like S-doped-Ni2P mesoporous nanosheet-derived self-standing electrocatalytic electrode for boosting hydrogen evolution." Nanotechnology 31, no. 46 (2020): 465401.
  4. Justyna, Katarzyna, Stanisław Leśniak, Ryszard B. Nazarski, Michał Rachwalski, Thien Y. Vu, Thi Kieu Xuan Huynh, Saïd Khayar, Alain Dargelos, Anna Chrostowska, and Curt Wentrup. "Flash Vacuum Thermolysis of N‐(3‐and 4‐Pyridylmethylidene)‐tert‐butylamines: Mechanisms of Formation of Pyrrolopyridines and Naphthyridines." European Journal of Organic Chemistry 2014, no. 14 (2014): 3020-3027.
  5. Thi, L. L. D., P. N. K. Tuyen, and Thien Y. Vu. "Flower-like S-doped-Ni2P mesoporous nanosheet-derived self-standing electrocatalytic electrode for boosting hydrogen evolution." Nanotechnology 31, no. 46 (2020): 465401.
ThS. Long

 

Vũ Huỳnh Kim Long, PhD Candidate

Positions: Member of APRES

Areas of expertise: Natural Products, Herbal Drugs Quality Control

Email: vuhuynhkimlong@tdt.edu.vn

Research track record:

  • ISI papers: 8
  • total ISI Citations: 13
  • ISI H-index:1
  • At most 5 top journals:
  1. Vu-Huynh, Kim Long, Huy Truong Nguyen, Thi Hong Van Le, Chi Thanh Ma, Gwang Jin Lee, Sung Won Kwon, Jeong Hill Park, and Minh Duc Nguyen. "Accumulation of Saponins in Underground Parts of Panax vietnamensis at Different Ages Analyzed by HPLC-UV/ELSD." Molecules 25, no. 13 (2020): 3086.
  2. Minh Nguyen, Hien, Huy Truong Nguyen, Nwet Win, Chin Piow Wong, Kim Long Vu Huynh, Nhat Nam Hoang, Kiep Minh Do et al. "Antimelanogenic Activity of Ocotillol‐Type Saponins from Panax vietnamensis." Chemistry & Biodiversity 17, no. 5 (2020): e2000037.
  3. Nguyen, C. D., T. L. M. Pham, T. Y. Vu, V. B. Mai, and K. L. Vu-Huynh. "Hierarchical Zn-Co-P nanoneedle arrays supported on three-dimensional framework as efficient electrocatalysts for hydrogen evolution reaction in alkaline condition." Journal of Electroanalytical Chemistry 858 (2020): 113803.
  4. Lee, Dahae, Jaemin Lee, Kim Long Vu-Huynh, Thi Hong Van Le, Thi Hong Tuoi Do, Gwi Seo Hwang, Jeong Hill Park, Ki Sung Kang, Minh Duc Nguyen, and Noriko Yamabe. "Protective Effect of Panaxynol Isolated from Panax vietnamensis against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies." Biomolecules 9, no. 12 (2019): 890.
  5. Vu-Huynh, Kim Long, Thi Hong Van Le, Huy Truong Nguyen, Hyung Min Kim, Ki Sung Kang, Jeong Hill Park, and Minh Duc Nguyen. "Increase in Protective Effect of Panax vietnamensis by Heat Processing on Cisplatin-Induced Kidney Cell Toxicity." Molecules 24, no. 24 (2019): 4627.
  6. Van Le, Thi Hong, Gwang Jin Lee, Huynh Kim Long Vu, Sung Won Kwon, Ngoc Khoi Nguyen, Jeong Hill Park, and Minh Duc Nguyen. "Ginseng saponins in different parts of Panax vietnamensis." Chemical and Pharmaceutical Bulletin 63, no. 11 (2015): 950-954.
  7. Image data for indentification of Panax crude drugs. Journal of Medicinal materials 5, 2012.
  8. Application of Solid phase extraction in quantiative determination of major saponins in Panax vietnamensis. Journal of Medicinal material 5, 2013.

5. Publications (ISI or Scopus only)

  1. Vu-Huynh, Kim Long, Huy Truong Nguyen, Thi Hong Van Le, Chi Thanh Ma, Gwang Jin Lee, Sung Won Kwon, Jeong Hill Park, and Minh Duc Nguyen. "Accumulation of Saponins in Underground Parts of Panax vietnamensis at Different Ages Analyzed by HPLC-UV/ELSD." Molecules 25, no. 13 (2020): 3086.
  2. Nguyen, Hien Minh, Huy Truong Nguyen, Nwet Win, Chin Piow Wong, Kim Long Vu Huynh, Nhat Nam Hoang, Kiep Minh Do et al. "Antimelanogenic Activity of Ocotillol-Type Saponins From Panax Vietnamensis." Chemistry & biodiversity 17, no. 5 (2020): e2000037.
  3. Vu-Huynh, Kim Long, Thi Hong Van Le, Huy Truong Nguyen, Hyung Min Kim, Ki Sung Kang, Jeong Hill Park, and Minh Duc Nguyen. "Increase in Protective Effect of Panax vietnamensis by Heat Processing on Cisplatin-Induced Kidney Cell Toxicity." Molecules 24, no. 24 (2019): 4627.
  4. Ma, Chi Thanh, Eunji Cho, Huy Truong Nguyen, Bo Wu, Thi Hong Van Le, Ki Bong Oh, Sung Won Kwon, Minh Duc Nguyen, and Jeong Hill Park. "Malacinones A and B, two novel sesquiterpenoids with 6/6/5 tricyclic ring system from the agarwood of Aquilaria malaccensis." Tetrahedron Letters 61, no. 1 (2020): 151355.

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