Le Quoc Viet, Ph.D.

Le Quoc Viet, Ph.D.

Position: Vice Dean ; Head - Department of Pharmaceutical Technology and Pharmacy Administration

Expertise: Pharmaceutics and Physical Pharmacy

Email: lequocviet@tdtu.edu.vn

Web of Science Google Scholar ORCID

Main Research Directions

  • Development of novel biomaterials for nanoformulation-based drug delivery.
  • Development of nanoparticle drug delivery systems for cancer therapy.
  • Evaluation of the immunological effects of nanomedicine systems.
  • Application of nanotechnology in next-generation vaccine development.
  • Application of physicochemical approaches to improve solubility and taste masking of oral formulations.

Education

  • 2015 – 2021: Doctor of Philosophy (Ph.D.) in Pharmaceutics and Physical Pharmacy, Seoul National University, South Korea
  • 2008 – 2013: Bachelor of Pharmacy (B.Pharm.), University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam

Experience

  • November 2021 – Present: Faculty of Pharmacy, Ton Duc Thang University

Publications

  1. Shim, Gayong, Seungbeom Ko, Dongyoon Kim, Quoc-Viet Le, Gyu Thae Park, Jaiwoo Lee, Taekhyun Kwon, Han-Gon Choi, Young Bong Kim, and Yu-Kyoung Oh. "Light-switchable systems for remotely controlled drug delivery." Journal of Controlled Release 267 (2017): 67-79.
  2. Shim, Gayong, Dongyoon Kim, Quoc-Viet Le, Gyu T. Park, Taekhyun Kwon, and Yu-Kyoung Oh. "Nonviral delivery systems for cancer gene therapy: strategies and challenges." Current gene therapy 18, no. 1 (2018): 3-20.
  3. Le, Quoc-Viet, Jinjoo Choi, and Yu-Kyoung Oh. "Nano delivery systems and cancer immunotherapy." Journal of Pharmaceutical Investigation 48, no. 5 (2018): 527-539.
  4. Le, Quoc-Viet, Geon Yang, Yina Wu, Ho Won Jang, Mohammadreza Shokouhimehr, and Yu-Kyoung Oh. "Nanomaterials for modulating innate immune cells in cancer immunotherapy." Asian Journal of Pharmaceutical Sciences 14, no. 1 (2019): 16-29.
  5. Le, Quoc-Viet, Juhan Suh, and Yu-Kyoung Oh. "Nanomaterial-based modulation of tumor microenvironments for enhancing chemo/immunotherapy." The AAPS Journal 21, no. 4 (2019): 1-19.
  6. Shim, Gayong, Quoc-Viet Le, Juhan Suh, Sunhee Choi, Gunwoo Kim, Han-Gon Choi, Young Bong Kim, Robert B. Macgregor Jr, and Yu-Kyoung Oh. "Sequential activation of anticancer therapy triggered by tumor microenvironment-selective imaging." Journal of Controlled Release 298 (2019): 110-119.
  7. Kim, Dongyoon, Quoc-Viet Le, Young Bong Kim, and Yu-Kyoung Oh. "Safety and photochemotherapeutic application of poly (γ-glutamic acid)-based biopolymeric nanoparticle." Acta Pharmaceutica Sinica B 9, no. 3 (2019): 565-574.
  8. Le, Quoc-Viet, Juhan Suh, Jin Joo Choi, Gyu Thae Park, Jung Weon Lee, Gayong Shim, and Yu-Kyoung Oh. "In situ nanoadjuvant-assembled tumor vaccine for preventing long-term recurrence." ACS nano 13, no. 7 (2019): 7442-7462.
  9. Lee, Jaiwoo, Quoc-Viet Le, Geon Yang, and Yu-Kyoung Oh. "Cas9-edited immune checkpoint blockade PD-1 DNA polyaptamer hydrogel for cancer immunotherapy." Biomaterials 218 (2019): 119359. (1 co-first authors).
  10. Choi, Jin Joo, Quoc-Viet Le, Dongho Kim, Young Bong Kim, Gayong Shim, and Yu-Kyoung Oh. "High molecular weight chitosan-complexed RNA nanoadjuvant for effective cancer immunotherapy." Pharmaceutics 11, no. 12 (2019): 680. (1 co-first authors).
  11. Yang, Hobin, Quoc-Viet Le, Gayong Shim, Yu-Kyoung Oh, and Young Kee Shin. "Molecular engineering of antibodies for site-specific conjugation to lipid polydopamine hybrid nanoparticles." Acta Pharmaceutica Sinica B 10, no. 11 (2020): 2212-2226. (1 co-first authors).
  12. Shim, Gayong, Seungbeom Ko, Joo Yeon Park, Ju Han Suh, Quoc-Viet Le, Dongyoon Kim, Young Bong Kim et al. "Tannic acid-functionalized boron nitride nanosheets for theranostics." Journal of Controlled Release 327 (2020): 616-626.
  13. Kim, Dongyoon, Quoc-Viet Le, Yina Wu, Jinwon Park, and Yu-Kyoung Oh. "Nanovesicle-mediated delivery systems for CRISPR/Cas genome editing." Pharmaceutics 12, no. 12 (2020): 1233. (1 co-first authors).
  14. Le, Quoc-Viet, Jaiwoo Lee, Hobin Lee, Gayong Shim, and Yu-Kyoung Oh. "Cell membrane-derived vesicles for delivery of therapeutic agents." Acta Pharmaceutica Sinica B 11, no. 8 (2021): 2096-2113. (1 co-first authors).
  15. Quoc‐Viet Le, Dongyoon Kim, Jaiwoo Lee, Gayong Shim, Yu‐Kyoung Oh. "Photosensitizer‐Free Phototherapy with Peptide Micelle Nanoadjuvants for Cancer Vaccine against Metastasis of Melanoma." Advanced Therapeutics 4, no. 8 (2021): 2000288.
  16. Jinwon Park, Jaehyun Choi, Dae-Duk Kim, Seunghee Lee, Bongjin Lee, Yunhee Lee, Sanghee Kim, Sungwon Kwon, Minsoo Noh, Mi-Ock Lee, Quoc-Viet Le*, Yu-Kyoung Oh*. "Bioactive lipids and their derivatives in biomedical applications." Biomolecules & Therapeutics 29, no. 5 (2021): 465.
  17. Jaiwoo Lee, Dongyoon Kim, Quoc-Viet Le*, Yu-Kyoung Oh*. "Nanotherapeutics for immune network modulation in tumor microenvironments." Seminars in Cancer Biology 86 (2022): 1066-1087.
  18. Jaiwoo Lee1, Quoc-Viet Le1, Seungbeom Ko, Sungtaek Kang, Robert B Macgregor Jr, Gayong Shim, Yu-Kyoung Oh. "Blood-declustering excretable metal clusters assembled in DNA matrix." Biomaterials 289 (2022): 121754. (1 co-first authors).
  19. Quoc‐Viet Le, J Lee, J Byun, G Shim, YK Oh. "DNA-based artificial dendritic cells for in situ cytotoxic T cell stimulation and immunotherapy." Bioactive Materials 15 (2022): 160-172.
  20. Y Wu, J Park, D Jin, J Lee, Quoc‐Viet Le,*, YK Oh*. "Tannic acid‐based nanomaterials for tolerogenic immunotherapy of rheumatoid arthritis." Advanced Functional Materials 33, no. 46 (2023): 2305563.
  21. Quoc‐Viet Le, J Lee, S Ko, H Kim, TY Vu, YS Choe, YK Oh, G Shim. "Enzyme‐responsive macrocyclic metal complexes for biomedical imaging." Bioengineering & Translational Medicine 8, no. 5 (2023): e10478.
  22. NTH Yen, JH Oh, NT Van Anh, Quoc‐Viet Le, SM Park, YJ Park, YS Cho, .... "Systems-level multi-omics characterization provides novel molecular insights into indomethacin toxicity." Chemico-Biological Interactions 375 (2023): 110430.
  23. J Park1, Quoc‐Viet Le,1, Y Wu, J Lee, YK Oh. "Tolerogenic nanovaccine for prevention and treatment of autoimmune encephalomyelitis." Advanced Materials 35, no. 1 (2023): 2202670. (1 co-first authors).
  24. Y Wu, J Park, Quoc‐Viet Le, J Byun, J Choi, E Xu, J Lee, YK Oh. "NET formation-mediated in situ protein delivery to the inflamed central nervous system." Nature Communications 15, no. 1 (2024): 10747.
  25. Quoc‐Viet Le, G Shim. "Biorobotic drug delivery for biomedical applications." Molecules 29, no. 15 (2024): 3663.
  26. BT Nguyen, Quoc‐Viet Le,*, J Ahn, KA Nguyen, HT Nguyen, JS Kang, NP Long, ... "Omics analysis unveils changes in the metabolome and lipidome of Caenorhabditis elegans upon polydopamine exposure." Journal of Pharmaceutical and Biomedical Analysis 244 (2024): 116126.
  27. NTH Yen, NTN Tien, NT Van Anh, Quoc‐Viet Le, C Eunsu, HS Kim, KS Moon, ... "Cyclosporine A-induced systemic metabolic perturbations in rats: A comprehensive metabolome analysis." Toxicology Letters 395 (2024): 50-59.
  28. Quoc‐Viet Le, S Kang, J Lee, H Park, JG Sun, J Lee, G Shim. "Size-dependent effect of indocyanine green nanoimaging agent for metastatic lymph node detection." Biomaterials Research 28 (2024): 22.
  29. J Park, Y Wu, Quoc‐Viet Le, JS Kim, E Xu, J Lee, YK Oh. "Self-disassembling nanoparticles as oral nanotherapeutics targeting intestinal microenvironment." Nature Communications 16, no. 1 (2025): 3365

Patents

  1. Oh, Yu-Kyoung, Jinwon Park, and Quoc-Viet Le. Lipid–biopolymer nanoparticles conjugated with antibodies and self-antigens on the surface and the use thereof. Korean Patent No. KR1027617220000. Published 2025 Feb 6.
  2. Oh, Yu-Kyoung, YoungKee Shin, Gayong Shim, Hobin Yang, and Quoc-Viet Le. Pharmaceutical composition for treatment of cancers comprising lipid-photothermal nanoparticle conjugated antibody. Korean Patent No. KR1026920090000. Published 2024 Aug 7.
  3. Oh, Yu-Kyoung, Shim, Gayong, & Le, Quoc-Viet. Pharmaceutical composition for treatment of cancers or inhibition of metastasis comprising photothermal nanoparticle conjugated immune checkpoint inhibitor and adjuvant. Korean Patent No. KR1021358400000. Published 2020 Jul 20.