Prof. Sukchan Lee
Research areas
Molecular plant-geminivirus interactions
Translational research: Side effect alleviation of cancer patients
Antiviral protein development: Nucleic acid hydrolytic catalytic antibody
Research activities
Research activities:
- Development of novel antiviral agents, including catalytic antibody-based therapeutics (e.g., 3D8 scFv) targeting a wide range of viruses such as influenza and coronaviruses
- Leading projects on detection and surveillance technologies for infectious viruses, including marine and emerging viral pathogens
- Conducting research plant virology and human/animal infectious diseases, expanding discoveries from plant virus systems to biomedical applications
- Publishing research on virus biology, antiviral strategies, and functional biomolecules, contributing to both academic knowledge and potential therapeutic innovation
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Publications |
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1 |
De Novo Transcriptome Assembly of Two Microsorum Fern Species Identifies Enzymes Required for Two Upstream Pathways of Phytoecdysteroids |
2021 |
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2 |
Broad-Spectrum Antiviral Activity of 3D8, a Nucleic Acid-Hydrolyzing Single-Chain Variable Fragment (scFv), Targeting SARS-CoV-2 and Multiple Coronaviruses In Vitro |
2021 |
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3 |
Adaptation and Codon-Usage Preference of Apple and Pear-Infecting Apple Stem Grooving Viruses |
2021 |
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4 |
Plum pox virus: diagnosis and spread inhibition by weed control |
2021 |
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5 |
Tomato Yellow Leaf Curl Virus Infection in a Monocotyledonous Weed (Eleusine indica) |
2021 |
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6 |
Identification of a Novel Geminivirus in Fraxinus rhynchophylla in Korea |
2021 |
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7 |
Zooming on dynamics of marine microbial communities in the phycosphere of Akashiwo sanguinea (Dinophyta) blooms |
2021 |
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8 |
Butein-Enriched Fractions of Butea monosperma (Lam.) Taub. Flower Decrease Weight Gains and Increase Energy Expenditure in High-Fat Diet-Induced Obese Mice |
2021 |
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9 |
Different Infectivity of Mediterranean and Southern Asian Tomato Leaf Curl New Delhi Virus Isolates in Cucurbit Crops |
2022 |
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10 |
First Report of Squash leaf curl China virus Associated with Mosaic and Mild Leaf Curl Disease of Pumpkin in Bangladesh |
2022 |
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11 |
Oral administration of Euglena gracilis paramylon ameliorates chemotherapy-induced leukocytopenia and gut dysbiosis in mice |
2022 |
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12 |
A Therapeutically Active Minibody Exhibits an Antiviral Activity in Oseltamivir-Resistant Influenza-Infected Mice via Direct Hydrolysis of Viral RNAs |
2022 |
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13 |
A Novel Approach of Antiviral Drugs Targeting Viral Genomes |
2022 |
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14 |
Enhancing neutralizing activity against influenza H1N1/PR8 by engineering a single-domain VL-M2 specific into a bivalent form |
2022 |
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15 |
Interspecies Recombination-Led Speciation of a Novel Geminivirus in Pakistan |
2022 |
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16 |
A Novel Specific Single-Chain Variable Fragment Diagnostic System for Viral Hemorrhagic Septicemia Virus |
2022 |
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17 |
Acquired lymphedema: Molecular contributors and future directions for developing intervention strategies |
2022 |
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18 |
Development of an Immunoassay Detection System for Koi Herpesvirus Using Recombinant Single-Chain Variable Fragments |
2022 |
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19 |
Occurrence and completed genomes of sweet potato chlorotic stunt virus infecting sweet potato in Korea |
2022 |
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20 |
ToLCNDV-ES infection in tomato is enhanced by TYLCV: Evidence from field survey and agroinoculation |
2022 |
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21 |
Thalassotalea daebudonensis sp. nov., isolated from the seashore sediment. |
2022 |
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22 |
Identification of begomoviruses associated with the insect vector Bemisia tabaci and various host plants on Java Island, Indonesia |
2023 |
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23 |
Genetic diversity of cryptic species of Bemisia tabaci in Asia |
2023 |
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24 |
An Effective Integrated Machine Learning Framework for Identifying Severity of Tomato Yellow Leaf Curl Virus and Their Experimental Validation |
2023 |
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25 |
First Report of Tomato Leaf Curl Bangladesh Virus Associated with Leaf Yellowing Symptoms in Lablab purpureus in Bangladesh |
2023 |
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26 |
Transcriptional Analysis of the Differences between ToLCNDV-India and ToLCNDV-ES Leading to Contrary Symptom Development in Cucumber |
2023 |
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27 |
Comparative Transcriptomic Analysis of Genes in the 20-Hydroxyecdysone Biosynthesis in the Fern Microsorum scolopendria towards Challenges with Foliar Application of Chitosan |
2023 |
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28 |
Tomato yellow leaf curl virus infection promotes the tolerance against drought stress in Solanum lycopersicum L. |
2023 |
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29 |
Construction of an Agroinfectious Clone of a Korean Isolate of Sweet Potato Symptomless Virus 1 and Comparison of Its Infectivity According to Agrobacterium tumefaciens Strains in Nicotiana benthamiana |
2023 |
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30 |
Insights into the Differential Composition of Stem-Loop Structures of Nanoviruses and Their Impacts |
2023 |
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31 |
Coat protein is responsible for tomato leaf curl New Delhi virus pathogenicity in tomato |
2023 |
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32 |
Replication of geminiviruses genomes is promoted by host factors |
2023 |
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33 |
M13KO7 bacteriophage enables Potato Virus Y detection |
2023 |
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34 |
Transreplication Preference of the Tomato Leaf Curl Joydebpur Virus for a Noncognate Betasatellite through Iteron Resemblance on Nicotiana bethamiana |
2023 |
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35 |
An RNA-hydrolyzing recombinant minibody prevents both influenza A virus and coronavirus in co-infection models |
2024 |
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36 |
A synergistic therapy against influenza virus A/H1N1/PR8 by a HA1 specific neutralizing single-domain VL and an RNA hydrolyzing scFv |
2024 |
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37 |
Twindemic Threats of Weeds Coinfected with Tomato Yellow Leaf Curl Virus and Tomato Spotted Wilt Virus as Viral Reservoirs in Tomato Greenhouses |
2024 |
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38 |
Advancing the accuracy of SARS-CoV-2 phosphorylation site detection via meta-learning approach |
2024 |
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39 |
A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress |
2024 |
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40 |
Butein derivatives prevent obesity and improve insulin resistance through the induction of energy expenditure in high-fat diet-fed obese mice |
2024 |
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41 |
Amelioration of Cancer Cachexia by Dalbergia odorifera Extract Through AKT Signaling Pathway Regulation |
2024 |
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42 |
The Insidious Threat: Assessing the Dangers and Spread of Tomato Leaf Curl New Delhi Virus |
2025 |
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43 |
Potential Broad-Spectrum Antiviral Agents against Influenza A Virus: Targeting Viral and Host Factors |
2025 |
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44 |
Molecular Dissection of Symptom Determinants in Tomato Leaf Curl New Delhi Virus in Zucchini Through Mechanical Transmission |
2025 |
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45 |
Regulatory role of stem-loop structures in Faba bean necrotic yellows virus replication efficiency |
2025 |
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46 |
Rapid detection of three IMO standard marine bacteria using recombinase polymerase amplification and lateral flow assay (RPA-LFA) |
2025 |
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47 |
Valproic Acid Enhances the Anticancer Effect of L-Ascorbic Acid by Upregulating Sodium-Dependent Vitamin C Transporter 2 in Colorectal Cancer |
2025 |
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48 |
Exploring the potential of ginseng-derived compounds in treating cancer cachexia |
2025 |
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49 |
Construction and Segmental Reconstitution of Full-Length Infectious Clones of Milk Vetch Dwarf Virus |
2025 |
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50 |
Tannic acid suppresses vitamin C’s hormetic effects in HCT-15 low-SVCT2-expressing colorectal cancer cells by upregulating SVCT2 |
2025 |
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51 |
Invasion and potential spread of the Bemisia tabaci Mediterranean (MED) Q2 subgroup in Korea |
2025 |
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52 |
First Report of Cucumber mosaic virus Infecting Helianthus annuus in Korea |
2026 |
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53 |
Biological Trajectory of Virophage Research and the Emergence of Marine Virophages: A Scoping Review |
2026 |
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54 |
DeepTYLCV: An interpretable and experimentally validated AI model for predicting virulence of different tomato yellow leaf curl virus strains |
2026 |
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55 |
Structure‐Guided Engineering of 3D8 scFv Enhances Stability and Antiviral Potential |
2026 |
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56 |
Antiviral Efficacy, Cytotoxicity, Transcriptomics, and Discriminatory Function of 3D8 scFv Against Dengue and Zika Viruses |
2026 |
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57 |
Therapeutic Potential of Polydatin Against Cancer Cachexia by Regulating the STAT3 Signaling Pathway |
2026 |
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58 |
Mild to Virulent: Coat Protein Mutations Restore Mosaic Symptom Induction in a Korean PepMV Isolate |
2026 |
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59 |
In silico prediction of faba bean necrotic yellows virus proteins and their interactions with host protein SnRK1 through expression analysis |
2026 |
