TS. Lê Quốc Việt

• Phát triển các vật liệu sinh học mới trong bào chế thuốc nano
• Phát triển hệ phân phối thuốc nano ứng dụng trong điều trị ung thư
• Đánh giá hoạt tính của hệ thuốc nano trên hệ miễn dịch
• Ứng dụng công nghệ thuốc nano trong phát triển vaccine thế hệ mới
• Ứng dụng các kỹ thuật hóa lý để tăng độ hòa tan và che vị trong các dạng bào chế đường uống

• 2008 - 2013: Dược sĩ đại học, Đại học Y Dược TP. Hồ Chí Minh
• 2015 - 2021: Tiến sĩ, chuyên ngành Bào chế - Hóa Lý Dược, Đại học quốc gia Seoul, Hàn Quốc

• 11/2021- nay : Khoa Dược, Trường Đại học Tôn Đức Thắng

Patent

1. Oh, Yu-Kyoung, Jinwon Park, and Quoc-Viet Le. Lipid–biopolymer nanoparticles conjugated with antibodies and self-antigens on the surface and the use thereof. Korean Patent No. KR1027617220000. Published 2025 Feb 6.
2. Oh, Yu-Kyoung, YoungKee Shin, Gayong Shim, Hobin Yang, and Quoc-Viet Le. Pharmaceutical composition for treatment of cancers comprising lipid-photothermal nanoparticle conjugated antibody. Korean Patent No. KR1026920090000. Published 2024 Aug 7.
3. Oh, Yu-Kyoung, Shim, Gayong, & Le, Quoc-Viet. Pharmaceutical composition for treatment of cancers or inhibition of metastasis comprising photothermal nanoparticle conjugated immune checkpoint inhibitor and adjuvant. Korean Patent No. KR1021358400000. Published 2020 Jul 20.

Quốc tế

1. Shim, Gayong, Seungbeom Ko, Dongyoon Kim, Quoc-Viet Le, Gyu Thae Park, Jaiwoo Lee, Taekhyun Kwon, Han-Gon Choi, Young Bong Kim, and Yu-Kyoung Oh. "Light-switchable systems for remotely controlled drug delivery." Journal of Controlled Release 267 (2017): 67-79.
2. Shim, Gayong, Dongyoon Kim, Quoc-Viet Le, Gyu T. Park, Taekhyun Kwon, and Yu-Kyoung Oh. "Nonviral delivery systems for cancer gene therapy: strategies and challenges." Current gene therapy 18, no. 1 (2018): 3-20.
3. Le, Quoc-Viet, Jinjoo Choi, and Yu-Kyoung Oh. "Nano delivery systems and cancer immunotherapy." Journal of Pharmaceutical Investigation 48, no. 5 (2018): 527-539.
4. Le, Quoc-Viet, Geon Yang, Yina Wu, Ho Won Jang, Mohammadreza Shokouhimehr, and Yu-Kyoung Oh. "Nanomaterials for modulating innate immune cells in cancer immunotherapy." Asian Journal of Pharmaceutical Sciences 14, no. 1 (2019): 16-29.
5. Le, Quoc-Viet, Juhan Suh, and Yu-Kyoung Oh. "Nanomaterial-based modulation of tumor microenvironments for enhancing chemo/immunotherapy." The AAPS Journal 21, no. 4 (2019): 1-19.
6. Shim, Gayong, Quoc-Viet Le, Juhan Suh, Sunhee Choi, Gunwoo Kim, Han-Gon Choi, Young Bong Kim, Robert B. Macgregor Jr, and Yu-Kyoung Oh. "Sequential activation of anticancer therapy triggered by tumor microenvironment-selective imaging." Journal of Controlled Release 298 (2019): 110-119.
7. Kim, Dongyoon, Quoc-Viet Le, Young Bong Kim, and Yu-Kyoung Oh. "Safety and photochemotherapeutic application of poly (γ-glutamic acid)-based biopolymeric nanoparticle." Acta Pharmaceutica Sinica B 9, no. 3 (2019): 565-574.
8. Le, Quoc-Viet, Juhan Suh, Jin Joo Choi, Gyu Thae Park, Jung Weon Lee, Gayong Shim, and Yu-Kyoung Oh. "In situ nanoadjuvant-assembled tumor vaccine for preventing long-term recurrence." ACS nano 13, no. 7 (2019): 7442-7462.
9. Lee, Jaiwoo, Quoc-Viet Le, Geon Yang, and Yu-Kyoung Oh. "Cas9-edited immune checkpoint blockade PD-1 DNA polyaptamer hydrogel for cancer immunotherapy." Biomaterials 218 (2019): 119359. (1 co-first authors).
10. Choi, Jin Joo, Quoc-Viet Le, Dongho Kim, Young Bong Kim, Gayong Shim, and Yu-Kyoung Oh. "High molecular weight chitosan-complexed RNA nanoadjuvant for effective cancer immunotherapy." Pharmaceutics 11, no. 12 (2019): 680. (1 co-first authors).
11. Yang, Hobin, Quoc-Viet Le, Gayong Shim, Yu-Kyoung Oh, and Young Kee Shin. "Molecular engineering of antibodies for site-specific conjugation to lipid polydopamine hybrid nanoparticles." Acta Pharmaceutica Sinica B 10, no. 11 (2020): 2212-2226. (1 co-first authors).
12. Shim, Gayong, Seungbeom Ko, Joo Yeon Park, Ju Han Suh, Quoc-Viet Le, Dongyoon Kim, Young Bong Kim et al. "Tannic acid-functionalized boron nitride nanosheets for theranostics." Journal of Controlled Release 327 (2020): 616-626.
13. Kim, Dongyoon, Quoc-Viet Le, Yina Wu, Jinwon Park, and Yu-Kyoung Oh. "Nanovesicle-mediated delivery systems for CRISPR/Cas genome editing." Pharmaceutics 12, no. 12 (2020): 1233. (1 co-first authors).
14. Le, Quoc-Viet, Jaiwoo Lee, Hobin Lee, Gayong Shim, and Yu-Kyoung Oh. "Cell membrane-derived vesicles for delivery of therapeutic agents." Acta Pharmaceutica Sinica B 11, no. 8 (2021): 2096-2113. (1 co-first authors).
15. Quoc‐Viet Le, Dongyoon Kim, Jaiwoo Lee, Gayong Shim, Yu‐Kyoung Oh. "Photosensitizer‐Free Phototherapy with Peptide Micelle Nanoadjuvants for Cancer Vaccine against Metastasis of Melanoma." Advanced Therapeutics 4, no. 8 (2021): 2000288.
16. Jinwon Park, Jaehyun Choi, Dae-Duk Kim, Seunghee Lee, Bongjin Lee, Yunhee Lee, Sanghee Kim, Sungwon Kwon, Minsoo Noh, Mi-Ock Lee, Quoc-Viet Le*, Yu-Kyoung Oh*. "Bioactive lipids and their derivatives in biomedical applications." Biomolecules & Therapeutics 29, no. 5 (2021): 465.
17. Jaiwoo Lee, Dongyoon Kim, Quoc-Viet Le*, Yu-Kyoung Oh*. "Nanotherapeutics for immune network modulation in tumor microenvironments." Seminars in Cancer Biology 86 (2022): 1066-1087.
18. Jaiwoo Lee1, Quoc-Viet Le1, Seungbeom Ko, Sungtaek Kang, Robert B Macgregor Jr, Gayong Shim, Yu-Kyoung Oh. "Blood-declustering excretable metal clusters assembled in DNA matrix." Biomaterials 289 (2022): 121754. (1 co-first authors).
19. Quoc‐Viet Le, J Lee, J Byun, G Shim, YK Oh. "DNA-based artificial dendritic cells for in situ cytotoxic T cell stimulation and immunotherapy." Bioactive Materials 15 (2022): 160-172.
20. Y Wu, J Park, D Jin, J Lee, Quoc‐Viet Le,*, YK Oh*. "Tannic acid‐based nanomaterials for tolerogenic immunotherapy of rheumatoid arthritis." Advanced Functional Materials 33, no. 46 (2023): 2305563.
21. Quoc‐Viet Le, J Lee, S Ko, H Kim, TY Vu, YS Choe, YK Oh, G Shim. "Enzyme‐responsive macrocyclic metal complexes for biomedical imaging." Bioengineering & Translational Medicine 8, no. 5 (2023): e10478.
22. NTH Yen, JH Oh, NT Van Anh, Quoc‐Viet Le, SM Park, YJ Park, YS Cho, .... "Systems-level multi-omics characterization provides novel molecular insights into indomethacin toxicity." Chemico-Biological Interactions 375 (2023): 110430.
23. J Park1, Quoc‐Viet Le,1, Y Wu, J Lee, YK Oh. "Tolerogenic nanovaccine for prevention and treatment of autoimmune encephalomyelitis." Advanced Materials 35, no. 1 (2023): 2202670. (1 co-first authors).
24. Y Wu, J Park, Quoc‐Viet Le, J Byun, J Choi, E Xu, J Lee, YK Oh. "NET formation-mediated in situ protein delivery to the inflamed central nervous system." Nature Communications 15, no. 1 (2024): 10747.
25. Quoc‐Viet Le, G Shim. "Biorobotic drug delivery for biomedical applications." Molecules 29, no. 15 (2024): 3663.
26. BT Nguyen, Quoc‐Viet Le,*, J Ahn, KA Nguyen, HT Nguyen, JS Kang, NP Long, ... "Omics analysis unveils changes in the metabolome and lipidome of Caenorhabditis elegans upon polydopamine exposure." Journal of Pharmaceutical and Biomedical Analysis 244 (2024): 116126.
27. NTH Yen, NTN Tien, NT Van Anh, Quoc‐Viet Le, C Eunsu, HS Kim, KS Moon, ... "Cyclosporine A-induced systemic metabolic perturbations in rats: A comprehensive metabolome analysis." Toxicology Letters 395 (2024): 50-59.
28. Quoc‐Viet Le, S Kang, J Lee, H Park, JG Sun, J Lee, G Shim. "Size-dependent effect of indocyanine green nanoimaging agent for metastatic lymph node detection." Biomaterials Research 28 (2024): 22.
29. J Park, Y Wu, Quoc‐Viet Le, JS Kim, E Xu, J Lee, YK Oh. "Self-disassembling nanoparticles as oral nanotherapeutics targeting intestinal microenvironment." Nature Communications 16, no. 1 (2025): 3365

Chương sách

1. Shim, Gayong, Dongyoon Kim, Quoc-Viet Le, Junho Byun, Jinwon Park, and Yu-Kyoung Oh. "Biomaterials for gene editing therapeutics." In Biomaterials for Cancer Therapeutics, pp. 187-231. Woodhead Publishing, 2020.

1. Outstanding paper award, Seoul National University 2020. “In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence”.
2. Best paper award, Biolipids Interactomics Research Center, Seoul National University 2020.