TS. Lê Thùy Hương

Hồ sơ giảng viên Faculty Profile
TS. Lê Thùy Hương

TS. Lê Thùy Hương Lê Thùy Hương

Học vị Tiến sĩ

Chức danh chuyên môn: Giảng viên

Bộ môn: Khoa học y sinh và Dược lý

Chuyên môn: Dược lý - Dược lâm sàng

Email: lethuyhuong@tdtu.edu.vn

Academic degree: Doctor

Academic title: Lecturer

Department: Department of Biomedical Science and Pharmacology

Specialization: Pharmacology and Clinical Pharmacy

Email: lethuyhuong@tdtu.edu.vn

Google Scholar ORCID Web of Science
 

🔬 Hướng nghiên cứu chính 🔬 Main Research Directions

  • Hướng nghiên cứu chính: Cơ chế bệnh sinh và điều trị ung thư
  • Đánh giá hoạt tính sinh học các hợp chất tự nhiên.
  • Nghiên cứu thuốc có khả năng ức chế alpha Glucosidase trong điều trị bệnh đái tháo đường tuýp 2
  • Ph.D. in Pharmacy – Seoul National University, Korea
  • Major: Pharmacology – Clinical Pharmacy
  • Main research interests: Pathogenesis and therapeutic strategies in cancer
  • Evaluation of biological activities of natural compounds

🧑‍🏫 Các môn giảng dạy tiêu biểu 🧑‍🏫 Teaching Subjects

  • Dược động học
  • Dược lý
  • Pharmacokinetics
  • Pharmacology

🎓 Quá trình đào tạo 🎓 Education

  • 2013-2021: Tiến sĩ Dược học, Đại học Quốc GIa Seoul, Hàn Quốc
  • 2006-2013: Dược sĩ đại học, Đại học Y Dược TP. Hồ Chí Minh
  • 2013–2021: Ph.D. in Pharmacy, Seoul National University, South Korea
  • 2006–2013: Bachelor of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam

🏢 Quá trình công tác 🏢 Professional Experience

  • 2020- nay: Khoa Dược, Đại học Tôn Đức Thắng
  • 2020–present: Faculty of Pharmacy, Ton Duc Thang University

📑 Công bố khoa học 📑 Publications

    1. Hyun, Seung Yeob, Huong Thuy Le, Cong-Truong Nguyen, Young-Sik Yong, Hye-Jin Boo, Ho Jin Lee, Ji-Sun Lee et al. "Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer." Scientific reports 8, no. 1 (2018): 1-16.
    2. Le, Huong Thuy, Huy Truong Nguyen, Hye-Young Min, Seung Yeob Hyun, Soonbum Kwon, Yeongcheol Lee, Thi Hong Van Le, Jeeyeon Lee, Jeong Hill Park, and Ho-Young Lee. "Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells." Cancer Letters 412 (2018): 297-307.
    3. Hyun SY, Le HT, Min HY, Pei H, Lim Y, Song I, Nguyen YTK, Hong S, Han BW, Lee HY. Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70. Theranostics. 2021 Jan 1;11(6):2932-2952. doi: 10.7150/thno.49876. PMID: 33456581; PMCID: PMC7806467.
    4. Le HT, Lee HJ, Cho J, Min HY, Lee JS, Lee SJ, Lee HY. Insulin-Like Growth Factor Binding Protein-3 Exerts Its Anti-Metastatic Effect in Aerodigestive Tract Cancers by Disrupting the Protein Stability of Vimentin. Cancers (Basel). 2021 Mar 2;13(5):1041. doi: 10.3390/cancers13051041. PMID: 33801272; PMCID: PMC7958122.
    5. Lee HJ, Min HY, Yong YS, Ann J, Nguyen CT, La MT, Hyun SY, Le HT, Kim H, Kwon H, Nam G, Park HJ, Lee J, Lee HY. A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects. Theranostics. 2022 Jan 1;12(1):105-125. doi: 10.7150/thno.63788. PMID: 34987637; PMCID: PMC8690924.
    6. Thuy Le H, Vu TY, Nguyen TV, Dinh Tri M, Pham NK, Truong Nguyen H, Nguyen NH, Nguyen HH, Duong TH. A New Carvotacetone Derivative from the Aerial Part of Sphaeranthus africanus. Chem Biodivers. 2023 Jun;20(6):e202300319. doi: 10.1002/cbdv.202300319. Epub 2023 May 30. PMID: 37183173.
    7. Nguyen NH, Duong TH, Truong Nguyen H, Vu YT, Tran TM, Ho TT, Mai CC, Mai DT, Nguyen HC, Thuy Le H, Pham DD. New Halogenated Flavonoids from Adenosma bracteosum and Vitex negundo and Their α-Glucosidase Inhibition. Chem Biodivers. 2023 Jul;20(7):e202300390. doi: 10.1002/cbdv.202300390. Epub 2023 Jun 28. PMID: 37293748.
    8. Do TH, Duong TH, Nguyen HH, Vo TS, Nguyen NH, Le HT. Comparative study of alpha-glucosidase inhibition of four Vietnamese medicinal plants Combretum quadrangulare, Dicranopteris linearis, Psychotria adenophylla, and Garcinia schomburgkiana: In vitro and in vivo studies. Biophys Physicobiol. 2024 Dec 13;21(4):e210027. doi: 10.2142/biophysico.bppb-v21.0027. PMID: 39963600; PMCID: PMC11832248.
    9. Thuy Le H, Vu YT, Duong GH, Le TK, Dang MK, Pham DD, Pham NK, Sichaem J, Nguyen NH, Duong TH. Bio-Guided Isolation of Alpha-Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei. Chem Biodivers. 2024 Jul;21(7):e202400438. doi: 10.1002/cbdv.202400438. Epub 2024 May 28. PMID: 38581153.
    10. Nguyen-Thi PT, Vo TK, Le HT, Nguyen NTT, Nguyen TT, Van Vo G. Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders. Pharm Res. 2024 Jun;41(6):1045-1092. doi: 10.1007/s11095-024-03718-x. Epub 2024 Jun 11. PMID: 38862719.
    11. Duong, Thuc-Huy, Thi-Minh-Dinh Tran, Phuong-Mai To, Nguyen-Hong-Nhi Phan, Thi-Phuong Nguyen, Huong Thuy Le, and Jirapast Sichaem. 2024. "Potential Antioxidant Compounds from the Spores of Dicranopteris linearis and the Branches of Averrhoa bilimbi" Antioxidants 13, no. 11: 1319. https://doi.org/10.3390/antiox13111319
    12. Le, H.T., Nguyen, T.-D., Do, A.-K., Nguyen, T.-P., Ngo, T.-M., Nguyen, T.-H., Bui, X.-H., Sichaem, J., Duong, T.-H. and Nguyen, N.-H. (2025), Alpha-Glucosidase and Nitric Oxide Inhibitors From Paramignya trimera Leaves and Dicranopteris linearis Spores: In Silico and In Vitro Aspects. Chem. Biodiversity e202500588. https://doi.org/10.1002/cbdv.202500588
    13. Kim H, Jin K, Lee JY, Yang TH, Oh S, Park S, Tran GB, Le HT, Pal K, Kim GJ, Kim D. Functional properties of hard kombucha brewed with deep ocean water using Lachancea thermotolerans. Sci Rep. 2025 Jul 24;15(1):26959. doi: 10.1038/s41598-025-12171-8. PMID: 40707548; PMCID: PMC12290105.
    1. Hyun, Seung Yeob, Huong Thuy Le, Cong-Truong Nguyen, Young-Sik Yong, Hye-Jin Boo, Ho Jin Lee, Ji-Sun Lee et al. "Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer." Scientific reports 8, no. 1 (2018): 1-16.
    2. Le, Huong Thuy, Huy Truong Nguyen, Hye-Young Min, Seung Yeob Hyun, Soonbum Kwon, Yeongcheol Lee, Thi Hong Van Le, Jeeyeon Lee, Jeong Hill Park, and Ho-Young Lee. "Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells." Cancer Letters 412 (2018): 297-307.
    3. Hyun SY, Le HT, Min HY, Pei H, Lim Y, Song I, Nguyen YTK, Hong S, Han BW, Lee HY. Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70. Theranostics. 2021 Jan 1;11(6):2932-2952. doi: 10.7150/thno.49876. PMID: 33456581; PMCID: PMC7806467.
    4. Le HT, Lee HJ, Cho J, Min HY, Lee JS, Lee SJ, Lee HY. Insulin-Like Growth Factor Binding Protein-3 Exerts Its Anti-Metastatic Effect in Aerodigestive Tract Cancers by Disrupting the Protein Stability of Vimentin. Cancers (Basel). 2021 Mar 2;13(5):1041. doi: 10.3390/cancers13051041. PMID: 33801272; PMCID: PMC7958122.
    5. Lee HJ, Min HY, Yong YS, Ann J, Nguyen CT, La MT, Hyun SY, Le HT, Kim H, Kwon H, Nam G, Park HJ, Lee J, Lee HY. A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects. Theranostics. 2022 Jan 1;12(1):105-125. doi: 10.7150/thno.63788. PMID: 34987637; PMCID: PMC8690924.
    6. Thuy Le H, Vu TY, Nguyen TV, Dinh Tri M, Pham NK, Truong Nguyen H, Nguyen NH, Nguyen HH, Duong TH. A New Carvotacetone Derivative from the Aerial Part of Sphaeranthus africanus. Chem Biodivers. 2023 Jun;20(6):e202300319. doi: 10.1002/cbdv.202300319. Epub 2023 May 30. PMID: 37183173.
    7. Nguyen NH, Duong TH, Truong Nguyen H, Vu YT, Tran TM, Ho TT, Mai CC, Mai DT, Nguyen HC, Thuy Le H, Pham DD. New Halogenated Flavonoids from Adenosma bracteosum and Vitex negundo and Their α-Glucosidase Inhibition. Chem Biodivers. 2023 Jul;20(7):e202300390. doi: 10.1002/cbdv.202300390. Epub 2023 Jun 28. PMID: 37293748.
    8. Do TH, Duong TH, Nguyen HH, Vo TS, Nguyen NH, Le HT. Comparative study of alpha-glucosidase inhibition of four Vietnamese medicinal plants Combretum quadrangulare, Dicranopteris linearis, Psychotria adenophylla, and Garcinia schomburgkiana: In vitro and in vivo studies. Biophys Physicobiol. 2024 Dec 13;21(4):e210027. doi: 10.2142/biophysico.bppb-v21.0027. PMID: 39963600; PMCID: PMC11832248.
    9. Thuy Le H, Vu YT, Duong GH, Le TK, Dang MK, Pham DD, Pham NK, Sichaem J, Nguyen NH, Duong TH. Bio-Guided Isolation of Alpha-Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei. Chem Biodivers. 2024 Jul;21(7):e202400438. doi: 10.1002/cbdv.202400438. Epub 2024 May 28. PMID: 38581153.
    10. Nguyen-Thi PT, Vo TK, Le HT, Nguyen NTT, Nguyen TT, Van Vo G. Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders. Pharm Res. 2024 Jun;41(6):1045-1092. doi: 10.1007/s11095-024-03718-x. Epub 2024 Jun 11. PMID: 38862719.
    11. Duong, Thuc-Huy, Thi-Minh-Dinh Tran, Phuong-Mai To, Nguyen-Hong-Nhi Phan, Thi-Phuong Nguyen, Huong Thuy Le, and Jirapast Sichaem. 2024. "Potential Antioxidant Compounds from the Spores of Dicranopteris linearis and the Branches of Averrhoa bilimbi" Antioxidants 13, no. 11: 1319. https://doi.org/10.3390/antiox13111319
    12. Le, H.T., Nguyen, T.-D., Do, A.-K., Nguyen, T.-P., Ngo, T.-M., Nguyen, T.-H., Bui, X.-H., Sichaem, J., Duong, T.-H. and Nguyen, N.-H. (2025), Alpha-Glucosidase and Nitric Oxide Inhibitors From Paramignya trimera Leaves and Dicranopteris linearis Spores: In Silico and In Vitro Aspects. Chem. Biodiversity e202500588. https://doi.org/10.1002/cbdv.202500588
    13. Kim H, Jin K, Lee JY, Yang TH, Oh S, Park S, Tran GB, Le HT, Pal K, Kim GJ, Kim D. Functional properties of hard kombucha brewed with deep ocean water using Lachancea thermotolerans. Sci Rep. 2025 Jul 24;15(1):26959. doi: 10.1038/s41598-025-12171-8. PMID: 40707548; PMCID: PMC12290105.