TS. Nguyễn Minh Hiền

Tiến sĩ Nguyễn Minh Hiền

Tiến sĩ Nguyễn Minh Hiền

Chức danh: Trợ lý Trưởng Khoa

Chuyên môn: Khoa học Dược (Hợp chất tự nhiên)

Email: nguyenminhhien@tdtu.edu.vn

Google Scholar ORCID Web of Science

🔬 Hướng nghiên cứu chính

  • Các hợp chất tự nhiên và dược liệu có hoạt tính sinh học

🎓 Quá trình đào tạo

  • 2015-2019: Tiến sĩ chuyên Khoa học Dược, Đại học Toyama, Nhật Bản
  • 2009-2011: Thạc sĩ chuyên ngành hóa hữu cơ, Đại học Cần Thơ
  • 2004-2008: Đại học chuyên ngành hóa, Đại học Cần Thơ

🏢 Quá trình công tác

  • 2019-nay: Khoa Dược, Trường Đại học Tôn Đức Thắng
  • 2011-2015: Kiểm nghiệm viên QC, Vemedim Cần Thơ

📑 Công bố khoa học

Quốc tế

  1. Ty VP, Thien-Y V and Nguyen HM (2025) Chemical profiles and biological activities of essential oil from Serissa japonica. Molecules 30(12), 24https://doi.org/10.3390/molecules30122485.
  2. An HN, Nguyen HM, Kiep MD & Huong LTN (2025) A new polyphenol and its derivatives with α glucosidase and nitric oxide production inhibitory activities from Ochna integerrima species in Vietnam. Nat Prod Res. https://doi.org/10.1080/14786419.2025.2507822.
  3. Linh TKN , Hien BTL, Thi VAT , Hoai TN , Duc VH and Nguyen HM (2024) Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of Homalomena pendula. Z Naturforsch C J Biosci. https://doi.org/10.1515/znc-2024-0152.
  4. Phuong VL, Nguyen HM, Phuc MP, An DV, & Huong LTN (2024). Testusterol, a new sterol of the sponge species Xestospongia testudinaria from Phu Quoc island, Vietnam. Nat Prod Res. https://doi.org/10.1080/14786419.2024.2340757.
  5. Nguyen HM, Khanh PN, An TPL, Nguyen HTN, Long KVH, Chi KTL, DA, Kenneth H & Daniel R (2024) Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr. Nat Prod Res https://doi.org/10.1080/14786419.2024.2378195.
  6. Iksen I, Natsaranyatron S, Nguyen HM, Hanh NTH, Duc VH, and Varisa P (2024) Adunctin E from Conamomum rubidum induces apoptosis in lung cancer via HSP90AA1 modulation: A network pharmacology and in vitro study. Int J Mol Sci 25(21), 11368, https://doi.org/10.3390/ijms252111368.
  7. Visarut B, Sornkanok V, Kittipong S, Asma B., Nguyen AB, Thach UD, Do BH, Van SD, Kiep MD, Nguyen HM (2023) Antioxidant, Anti-Skin aging, Anti-inflammatory, and Anti-acetylcholinesterase activities of Rourea oligophlebia extracts. Chem Biodivers. https://doi.org/10.1002/cbdv.202201096.
  8. Linh TKN, Hung QV, Hanh NTH, Thi VAT, Nguyen HM, Ty VP, Hang PTN, Thanh Pham & Duc VH 2023 Structure revision and absolute configuration of 5,7-diepi-2α-hydroxyoplopanone and anti-osteoporotic activities of sesquiterpenoids from the rhizomes of Homalomena pendula. Nat Prod Res 201-https://doi.org/10.1080/14786419.2023.2180505.
  9. Hien BTL, Van ATT, Nguyen HM, Linh TKN, Duc VH and Hoai TN 2023 Aspidiata E, a new spirostanol saponin from Aspidistra triradiata and its Cytotoxic Activity. Nat Prod Comm 18 1-https://doi.org/10.1177/1934578X231179412.
  10. Iksen I, Wasita W, Tanakrit W, Chutipa S, Natapol P, Natsaranyatron S, Nguyen HM & Varisa P 2023 Identifying molecular targets of Aspiletrein‑derived steroidal saponins in lung cancer using network pharmacology and molecular docking‑based assessments. Sci Rep 13:1545-15https://doi.org/10.1038/s41598-023-28821-8.
  11. Hien Bich Thi Le, Duc Viet Ho, Nguyen HM, Van Anh Thi Tran, Hoai Thi Nguyen (2023) Aspidiatas C and D, two new spirostanol saponins from Aspidistra triradiata and their cytotoxic activities. Nat Prod Res 26;1-9, https://doi.org/10.1080/14786419.2023.2204432.
  12. Kiep MD, Takeshi K, Nguyen HM, Naoki I, Chigusa S, Ken-Ichi S, Morita H (2022) Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities. Phytochem 25, 1135https://doi.org/10.1016/j.phytochem.2022.113510.
  13. Wasita W., Nguyen HM, Ho DV, Nguyen HT, Pithi C, Chanida V, Varisa P (2022) Aspiletrein A induces apoptosis cell death via increasing reactive oxygen species generation and AMPK activation in non-small-cell lung cancer cells. Int J Mol Sci, 23: 92https://doi.org/10.3390/ijms23169258.
  14. Visarut B, Khwanlada K, Sornkanok V, Asma B, Kittipong S, Thien-Y. V, Kim LV H, Bao L, Huy TN, Kiep MD, Van SD, Nguyen HM (2022) Some antioxidant properties of components from the flower of Ochna integerrima and their beneficial effects on HaCaT keratinocytes and in silico analysis on tyrosinase. Chem Biodivers. 19: e2021008https://doi.org/10.1002/cbdv.202100882.
  15. Le NT, Hoang NT, Van VTT, Nguyen TPD, Chau NHT, Le NTN, Le HBT, HT Phung, Nguyen HT, and Nguyen HM (2022) Extraction of curcumin from turmeric residue (Curcuma longa L.) using deep eutectic solvents and surfactant solvents. Anal. Methods 14, 8https://doi.org/10.1039/D1AY02152D.
  16. Kodama T, Min-Kyoung Shin, Ton NLH, Nguyen HM, Dang SV, Shiokawa K, Hayakawa Y, Morita H (2022) Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia, Phytochemistry 169: 1131https://doi.org/10.1016/j.phytochem.2022.113109
  17. Do MH, Khuat KVT, Huynh PT, Nguyen LNT, Do BH, Pham PD, Nguyen DH, Nguyen HM, Thach UD (2022) Synthesis, characterization, and antibacterial activity of amino-functionalized microcrystalline cellulose derivatives from cotton fibers, Biomass Convers Biorefin. https://doi.org/10.1007/s13399-022-02391-7.
  18. Do KM, Shin MK, Kodama T, Win NN, Prema P, Nguyen HM, Hayakawa Y, Morita H (2021) Flavanols and flavanes from Crinum asiaticum and their effects on LPS signaling pathway through the inhibition of NF-κB activation. Planta Med 88: 913-9https://doi.org/10.1055/a-1585-5877.
  19. Huy TN, Kim L VH, Nguyen HM, Huong TL, Thi HVL, Jeong HP, and Minh DN (2021) Evaluation of the saponin content in Panax vietnamensis acclimatized to Lam Dong province by HPLC–UV/CAD, Molecules 26: 5373-53https://doi.org/10.3390/molecules26175373.
  20. Duc VH, Hoai TN, Y TV, Ty VP, and Nguyen HM (2021) Antioxidant activity of a new xanthone derivative from Aspidistra Letreae: In vitro and in silico studies, Chem Biodivers 14: e20010https://doi.org/10.1002/cbdv.202001008.
  21. Nguyen HM, Hoai TN, Suthasinee S, Hang DB, Huy TN, Duc VH and Varisa P (2021), Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells, BMC Complementary Medicine and Therapies 21: 87-https://doi.org/10.1186/s12906-021-03262-w.
  22. Ty VP, Hanh NTH, Hoai TN, Nguyen HM, Cong TH, Y TV, Anh TD, Nguyen HN, and Hang DB (2021) Anti-Inflammatory and antimicrobial activities of compounds isolated from Distichochlamys benenica, BioMed Research International, 66243https://doi.org/10.1155/2021/6624347.
  23. Nguyen HM, Nguyen HT, Win NN, Wong CP, Vu HKL, Hoang NN, Do KM, Nguyen HT, Ho DV, Nguyen DM, Morita H (2020) Anti-melanogenic activity of ocotillol‐type saponins from Panax vietnamensis. Chem Biodivers 1: e20000https://doi.org/10.1002/cbdv.202000037.
  24. Duc VH, Hanh NTH, Hung QV, Khan VN, Ty VP, Anh TL, Kiem VP, Nguyen HM, Hoai NT, Morita H (2020) Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities. J Nat Med 74: 591-5https://doi.org/10.1007/s11418-020-01395-9.
  25. Khan VN, Duc VH, Nguyen HM, Thao TD, Kiem VP, Morita H, Jyrki H, Ain R and Hoai NT (2020) Chiro-Inositol derivatives from Chisocheton paniculatus showing Inhibition of nitric oxide production. J. Nat. Prod 83: 1201-12https://doi.org/10.1021/acs.jnatprod.9b01239.
  26. Ki DW, Kodama T, Ahmed H. El‐D, Wong CP, Nguyen HM, Do KM, Thai QM, Ton Nu LH, Morita H (2020) Chemical constituents of the Vietnamese marine sponge Gelliodes sp. and their cytotoxic activities. Chem Biodivers. 17: e20003https://doi.org/10.1002/cbdv.202000303.
  27. Hue BTB, Nguyen HM, Hieu MV, Thanh DLD, Son NH, De TQ, Morita H (2019) Facile sodium metabisulfite mediated systhesis of 1,2-disubstituted benzimidasoles and cytotoxicity evaluation. Heterocycles 98: 650-665.
  28. Ito T, Nguyen HM, Win NN, Hung VQ, Hoai NT, Morita H (2018) Three new sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp. and their biological activities. J Nat Med 72: 298-303.
  29. Nguyen HM, Ito T, Kurimoto S, Ogawa M, Win NN, Kodama T, Hung VQ, Hoai NT, Kubota T, Kobayashi J, Morita H (2017) New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities. Bioorg Med Chem Lett 27: 3043-3047.
  30. Duc HV, Hanh HTN, Hung VQ, Nguyen HM, Raal A, Hoai NT (2017) A new triterpene ester and other chemical constituents from the aerial parts of Anodendron paniculatum and their cytotoxic activity. J Asian Nat Prod Res 20: 188-194.
  31. Hoai NT, Duc HV, Hung VQ, Anh LT, Nguyen HM, Ito T, Kodama T, Morita H, Raal A (2017) Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera. Pharm Biol 55: 787-791.
  32. Duc HV, Hanh HTN, Hung VQ, Kiem PV, Anh TL, Ty PV, Nguyen HM, Ito T, Kodama T, Morita H, Raal A, Hoai NT (2017) Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum. Phytochemistry 144: 113-118.
  33. Nguyen HM, Ito T, Win NN, Kodama T, Hung VQ, Hoai NT, Morita H (2016) New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp. Phytochem Lett 17: 288-292.

Trong nước

  1. Nguyen PLG, Bui MP, Nguyen NHN, Ton NLH, Nguyen HM (2025) α-Amylase and α-Glucosidase inhibitory activities of the flower extracts from Ochna integerrima. Journal of Medicinal Materials, 30: 125-131. https://doi.org/10.63240/jmm-nimm.2025.2.116.
  2. Tu QT, Nguyen PK, Nguyen THN, Le PTA, Vu HKL, Ton NLH, Nguyen HM (2024) Antioxidant and anti-inflammatory effects of Ochna integerrima leaf extracts. Journal of Medicinal Materials, 29: 170-176.
  3. Nguyen THN, Phan TL, Le PTA, Nguyen PK, Nguyen HA, Ton NLH, Nguyen BA, Le TKC, Nguyen HM 2023 Antioxidant and anti-inflammatory potential from Ochna integerrima stem. Journal of Medicinal Materials, 28: 185-191.
  4. Ton NLH, Vu HKL, Thach UD, Tran TTT, Le TNT, Do DT, Le TKC, Nguyen HM (2022) Microscopic characteristics, antioxidant activities, and chemical compositions of Ochna integerrima leaves and stems. Journal of Medicinal Materials, 27: 227-234.
  5. Ton NLH, Nguyen TV, Le TP and Nguyen HM (2021) Investigation on the antifungal coating of oranges. Can Tho University Journal of Science 57: 143-150 (Vietnamese).

Hội thảo

  1. The 4th International conference on natural product discovery and development in the genomic era-the society for industrial microbiology and biotechnology (SIMB), 2023, San Diego, U.S.
  2. AsiaPharm V international conference (2023), Ton Duc Thang University, Vietnam.
  3. 1st Core-to-Core International Biosymposium (2024), Hiroshima University, Japan.
  4. Asian-Toyama Traditional Medicine Network (2025), Toyama University, Japan.

Tham gia bình duyệt

  1. Chemistry and biodiversity (6)
  2. Chemistry Select (4)
  3. RCS advances (1)
  4. ChemistryOpen (2)
  5. ChemPlusChem (2)
  6. Pharmaceuticals (1)

🎗️ Giải thưởng

  1. Từ 10/2015 đến 3/2019 (Nghiên cứu sinh): Japanese Government (Monbukagakusho: MEXT) Scholarship Hosted by Prof. Hiroyuki Morita, Toyama University, Japan
  2. Từ 09/2022 đến 01/2023: Fulbright Fund- Vietnamese Scholar Program- United States Hosted by Prof. Romo Daniel, Baylor University, Texas, U.S.