Introduction to the Research Group in Pharmaceutical and Biomedical Sciences – Faculty of Pharmacy
1. General Overview
The Leading Research Group of the Faculty of Pharmacy, under Ton Duc Thang University, is a pioneering research unit specializing in the discovery and development of medicinal compounds, pharmaceutical formulation technologies, quality control, and the application of natural products in disease treatment.
- Vietnamese Name: Nhóm nghiên cứu Dược học và Khoa học Y sinh
- English Name: Research Group in Pharmaceutical and Biomedical Sciences
- Abbreviation: BIOPHARMED
- Brochure: download
2. Objectives
- To advance research and innovation in pharmaceutical and biomedical sciences, with a strong emphasis on high-quality scientific publications, intellectual property, and technology transfer.
- To develop and nurture a new generation of talented and innovative researchers, contributing to the growth of high-quality human resources in the healthcare and life sciences sectors.
3. Main Research Areas
- Discovery and development of novel bioactive compounds from natural and synthetic sources for therapeutic and healthcare applications.
- Elucidation of drug mechanisms of action at the molecular and cellular levels.
- Technology transfer and development of pharmaceuticals, nutraceuticals, and cosmetic products.
4. Research Group Members
Group Leader
Specialization: Pharmacognosy
Degree: Ph.D. in Pharmaceutical Sciences, Hiroshima University, Japan
Email: nguyenminhduc@tdtu.edu.vn
Key Member
Specialization: Analytical Chemistry and Pharmaceutical Analysis
Degree: Ph.D. in Pharmaceutical Sciences, Seoul National University, South Korea
Email: nguyentruonghuy@tdtu.edu.vn
Key Member
Specialization: Pharmaceutics and Physical Pharmacy
Degree: Ph.D. in Pharmaceutical Sciences, Seoul National University, South Korea
Email: lequocviet@tdtu.edu.vn
Key Member
Specialization: Natural Products Chemistry
Degree: Ph.D. in Pharmaceutical Sciences, University of Toyama, Japan
Email: nguyenminhhien@tdtu.edu.vn
Key Member
Specialization: Pharmaceutical Biotechnology
Degree: Ph.D. in Biotechnology and Chemical Engineering, Chonnam National University, South Korea
Email: lebao@tdtu.edu.vn
Key Member
Specialization: Molecular Medicine
Degree: Ph.D. in Molecular Medicine, Chonnam National University, South Korea
Email: trangiabuu@tdtu.edu.vn
Member
Specialization: Chemistry and Physical Chemistry of Materials
Degree: Ph.D. in Chemistry and Physical Chemistry of Materials, University of Montpellier, France
Email: thachutdong@tdtu.edu.vn
Member
Specialization: Biomedical Sciences
Degree: Ph.D. in Biomedical Sciences, University of Ulsan, South Korea
Email: dobichhang@tdtu.edu.vn
Member
Specialization: Pharmacognosy and Traditional Medicine
Degree: Ph.D. in Traditional Medicine (Pharmaceutical Sciences), University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
Email: vuhuynhkimlong@tdtu.edu.vn
Member
Specialization: Physiology and Pathophysiology
Degree: Ph.D. in Pharmaceutical Sciences (Physiology and Pathophysiology), Seoul National University, South Korea
Email: lethuyhuong@tdtu.edu.vn
Member
Specialization: Pharmacology, Toxicology, and Clinical Pharmacy
Degree: Ph.D. in Pharmaceutical Sciences, Kangwon National University, South Korea
Email: phamductoan@tdtu.edu.vn
Member
Specialization: Neuroscience
Degree: Ph.D., University of Tasmania, Australia
Email: nguyenphuongtram@tdtu.edu.vn
Thành viên,
Specialization: Pharmaceutical Analysis
Degree: Ph.D. in Pharmacy, Kangwon National University, South Korea
Email: maixuanlan@tdtu.edu.vn
5. Selected Notable Publications (Group Members as First or Corresponding Authors)
-
Nguyen HM, Nguyen PK, Le PTA, Nguyen THN, Vu HKL, LeTKC, Anjana Delpe A, Kenneth H.& Daniel R. (2024), Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr, Natural Product Research 17:1-11.
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Nguyen HM, Ty VP, Hung QV, Hoai TN, Linh TKN, Bao CN, Khanh L.C. and Duc V.H. (2024) Essential oil from Vietnamese Peperomia leptostachya Hook. & Arn. (Piperaceae): Chemical composition, antioxidant, anti-inflammatory, cytotoxic activities, and in silico analysis, Molecules 29: 2808-2822.
- Thuy Le H, Vu YT, Duong GH, Le TK, Dang MK, Pham DD, Pham NK, Sichaem J, Nguyen NH, Duong TH. Bio-Guided Isolation of Alpha-Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei. Chem Biodivers. 2024 Jul;21(7):e202400438. doi: 10.1002/cbdv.202400438. Epub 2024 May 28. PMID: 38581153. https://doi.org/10.1002/cbdv.202400438
- Tran, G. B., Pham, T. V., Tuan Le, A., Nguyen, N. H., Vo, N. H. H., & Do, B. H. (2024). Chemical composition and the anti-inflammatory effect of volatile compounds from Anaxagorea luzonensis A. Gray. Zeitschrift fur Naturforschung. C, Journal of biosciences, 79(9-10), 329–336. https://doi.org/10.1515/znc-2023-0177
- Le Q.V., Kang S., Lee J., Park H., Sun J.G., Lee J., Shim G. Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection. Biomaterials Research 2024; 28, 0022.
- Le, B., Hong, V. T. K., & Yang, S. H. (2024). Anti-Inflammatory Effects of Hydroethanolic Extract from Ehretia asperula on Lipopolysaccharide-Stimulated RAW264. 7 Macrophages. Journal of Microbiology and Biotechnology, 34(6), 1340. https://doi.org/10.4014/jmb.2403.03006
- Nguyen, H. T., Phan, L. K., Huynh, K. L. V., Duong, T. H., Le, H. T., Hai-Yen, N. T., ... & Nguyen, M. D. (2023). Untargeted Metabolomics Approach for the Differentiation between Panax vietnamensis var. vietnamensis and Panax vietnamensis var. fuscidiscus. Metabolites, 13(6), 763.
- Thuy Le H, Vu TY, Nguyen TV, Dinh Tri M, Pham NK, Truong Nguyen H, Nguyen NH, Nguyen HH, Duong TH. A New Carvotacetone Derivative from the Aerial Part of Sphaeranthus africanus. Chem Biodivers. 2023 Jun;20(6):e202300319. doi: 10.1002/cbdv.202300319. Epub 2023 May 30. PMID: 37183173. https://doi.org/10.1002/cbdv.202300319
- Nguyen, H. T., Phan, L. K., Huynh, K. L. V., Duong, T. H., Le, H. T., Hai-Yen, N. T., ... & Nguyen, M. D. (2023). Untargeted Metabolomics Approach for the Differentiation between Panax vietnamensis var. vietnamensis and Panax vietnamensis var. fuscidiscus. Metabolites, 13(6), 763.
- Tran, G. B., Ding, J., Ye, B., Liu, M., Yu, Y., Zha, Y., Dong, Z., Liu, K., Sudarshan, S., & Ding, H. F. (2023). Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma. Cancer research, 83(13), 2248–2261. https://doi.org/10.1158/0008-5472.CAN-22-3450
- Le, B., Do, D. T., Nguyen, H. M., Do, B. H., & Le, H. T. (2022). Preparation, characterization, and anti-adhesive activity of Sulfate polysaccharide from Caulerpa lentillifera against Helicobacter pylori. Polymers, 14(22), 4993. https://doi.org/10.3390/polym14224993
- Le, B., Kim, D. G., Phuoc, N. N., Linh, N. T. H., & Yang, S. H. (2022). Dietary supplementation with Pediococcus pentosaceus enhances the innate immune response in and promotes growth of Litopenaeus vannamei shrimp. Journal of Fish Diseases, 45(9), 1343-1354. https://doi.org/10.1111/jfd.13666
- Le Q.V., Lee J, Ko S, Kim H, Vu TY, Choe YS, Oh YK, Shim G. Enzyme-responsive macrocyclic metal complexes for biomedical imaging. Bioeng Transl Med. 2022 Dec 21;8(5):e10478
- Nguyen, H. T., Vuong Bui, N. T., Kanhounnon, W. G., Vu Huynh, K. L., Nguyen, T.-V.-A., Nguyen, H. M., Do, M. H., Badawi, M., & Thach, U. D. (2021). Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation [10.1039/D1RA05505D]. RSC Advances, 11(54), 34281-34290. https://doi.org/10.1039/D1RA05505D
- Thach, U. D., Nguyen Thi, H. H., Pham, T. D., Mai, H. D., & Nhu-Trang, T.-T. (2021). Synergetic Effect of Dual Functional Monomers in Molecularly Imprinted Polymer Preparation for Selective Solid Phase Extraction of Ciprofloxacin. Polymers, 13(16), 2788. https://www.mdpi.com/2073-4360/13/16/2788
- Le HT, Lee HJ, Cho J, Min HY, Lee JS, Lee SJ, Lee HY. Insulin-Like Growth Factor Binding Protein-3 Exerts Its Anti-Metastatic Effect in Aerodigestive Tract Cancers by Disrupting the Protein Stability of Vimentin. Cancers (Basel). 2021 Mar 2;13(5):1041. doi: 10.3390/cancers13051041. PMID: 33801272; PMCID: PMC7958122. https://doi.org/10.3390/cancers13051041
- Le, B., Anh, P. T. N., & Yang, S. H. (2021). Polysaccharide derived from Nelumbo nucifera lotus plumule shows potential prebiotic activity and ameliorates insulin resistance in HepG2 cells. Polymers, 13(11), 1780. https://doi.org/10.3390/polym13111780
- Nguyen, H. T., Vu-Huynh, K. L., Nguyen, H. M., Le, H. T., Le, T. H. V., Park, J. H., & Nguyen, M. D. (2021). Evaluation of the saponin content in Panax Vietnamensis acclimatized to lam dong province by HPLC–UV/CAD. Molecules, 26(17), 5373.
- Le, Q.V.1; Lee, J.1; Lee, H.; Shim, G.; Oh, Y.K. Cell membrane-derived vesicles for delivery of therapeutic agents. Acta Pharm. Sin. B 2021, 11, 2096-2113. (1 co-first authors).
- Le, Q.V., Kim, D., Lee, J., Shim, G.; Oh, Y.-K. Photosensitizer-Free Phototherapy with Peptide Micelle Nanoadjuvants for Cancer Vaccine against Metastasis of Melanoma. Adv. Therap. 2021, 4, 2000288.
- Vu-Huynh, K. L., Nguyen, H. T., Van Le, T. H., Ma, C. T., Lee, G. J., Kwon, S. W., ... & Nguyen, M. D. (2020). Accumulation of saponins in underground parts of Panax vietnamensis at different ages analyzed by HPLC-UV/ELSD. Molecules, 25(13), 3086.
- Vu-Huynh, K. L., Truong, B. V., Bui, V. H., Thanh, H. N. T., & Dang, V. S. (2020, November). Vaccinium chlaenophyllum (Ericaceae), a new species from the Central Highlands of Vietnam. In Annales Botanici Fennici (Vol. 58, No. 1-3, pp. 15-18). Finnish Zoological and Botanical Publishing Board.
- Le, B., Ngoc, A. P. T., & Yang, S. H. (2020). Synbiotic fermented soymilk with Weissella cibaria FB069 and xylooligosaccharides prevents proliferation in human colon cancer cells. Journal of applied microbiology, 128(5), 1486-1496. https://doi.org/10.3390/foods9020181
- Le, B., Anh, P. T. N., & Yang, S. H. (2020). Enhancement of the anti-inflammatory effect of mustard kimchi on RAW 264.7 macrophages by the Lactobacillus plantarum fermentation-mediated generation of phenolic compound derivatives. Foods, 9(2), 181.
6. Completed and Ongoing Research Projects (Principal Investigator)
|
No. |
Project Title and Code |
Principal Investigator |
Duration |
Funding Agency |
Status |
|
1 |
Investigation of the inhibitory activity against Helicobacter pylori using symbiotic biological products Code: 47/2021/HĐ-KHCNT-VƯ |
Le Bao |
12/2021 - 12/2022 |
Department of Science and Technology, Ho Chi Minh City |
Completed and accepted |
|
2 |
Study on the production process of extract and instant tea from Vietnamese Codonopsis (Codonopsis javanica (Blume) Hook. f. – Campanulaceae) cultivated in Lam Dong Province Code: 2022-34/KQNC |
Nguyen Minh Duc |
2019-2021 |
Department of Science and Technology, Lam Dong Province |
Completed and accepted |
|
3 |
Study on saponin accumulation by plant age and its application in high-value products from Vietnamese ginseng (Panax vietnamensis Ha et Grushv. – Araliaceae) cultivated in Lam Dong Province Code: 2022-1303 |
Nguyen Minh Duc |
2019-2021 |
Department of Science and Technology, Ho Chi Minh City |
Completed and accepted |
| 4 |
Molecularly Imprinted Polymers (MIP) for Solid Phase Extraction (SPE) applications Code: GUST.STS.ĐT2018-HH03 |
Thach Ut Dong |
2018-2020 |
Vietnam Academy of Science and Technology |
Completed and accepted |
| 5 |
Screening for potent anti-COVID-19 compounds from Phyllanthus acidus and Phyllanthus emblica Code: 108.05-2023.35 |
Nguyen Truong Huy | 2024-2027 | NAFOSTED | Ongoing |
7. Intellectual Property, Technology Transfer, and Applied S&T Products
- Nguyen Minh Duc; Jeong Hill Park; Sung Won Kwon; Gwang Jin Lee; Nguyen Truong Huy; Le Thi Hong Van; Vu Huynh Kim Long, Process for the quantification of major saponins in Vietnamese ginseng (2019). Utility Solution, No. VN-0002205.
- Nguyen Minh Duc, Nguyen Truong Huy, Trương Công Trị, Vu Huynh Kim Long, Process for the production of honey-processed ginseng products (2022). Utility Solution, No. VN2-0003583.
8. Book Chapters, Monographs, and Teaching Materials (Last 5 Years)
- Shim, G.; Kim. D.; Le, Q.V.; Byun, J.; Park, J.; Oh, Y.K. “8 - Biomaterials for gene editing therapeutics”. Biomaterials for Cancer Therapeutics (Second Edition), edited by Park, K. Woodhead Publishing 2020, 187 - 231.
- Nguyễn Minh Đức, Trương Công Trị - Nanoparticles: Preparation Techniques, Characterization, Properties, and Applications in Pharmacy, Medical Publishing House, Ho Chi Minh City, 2020.
- Nguyễn Minh Đức, Sắc ký lỏng hiệu năng cao và một số ứng dụng trong nghiên cứu, kiểm nghiệm dược phẩm, dược liệu và hợp chất tự nhiên, Nhà xuất bản Y học TP. Hồ Chí Minh, 2006.
- Nguyen Minh Duc, Ryoji Kasai, Kazuhiro Ohtani, Aiko Ito, Kazuo Yamasaki, Nguyen Thoi Nham & Osamu Tanaka, New Saponins from Vietnamese Ginseng: Highlights on Biogenesis of Dammarane Triterpenoids. In: Waller, G.R., Yamasaki, K. (eds) Saponins Used in Traditional and Modern Medicine. Advances in Experimental Medicine and Biology, vol 404. Springer, Boston, MA.
- Tôn Nữ Liên Hương, Nguyễn Minh Hiền, Kỹ thuật chiết tách hợp chất tự nhiên, Nhà xuất bản Đại học Cần Thơ, 2024.
9. Các giải thưởng về Khoa học và Công nghệ
|
Tên công trình |
Tác giả |
Tên giải thưởng |
Cấp khen thưởng |
Thời gian |
|
Nghiên cứu bào chế và thử nghiệm tác dụng hạ acid uric máu của viên nang DR từ Diệp hạ châu đắng (Phyllanthus amarus) và Râu mèo (Orthosiphon aristatus) |
Nguyễn Minh Đức |
Giải Ba Hội thi Sáng tạo Kỹ thuật TP. Hồ Chí Minh lần thứ 26 (2019-2020) |
Sở Khoa học và Công nghệ TPHCM |
2019 |
| Xây dựng quy trình chiết xuất công nghiệp và nâng cao tiêu chuẩn chất lượng Cao dược liệu phục vụ sản xuất thuốc và xuất khẩu | Nguyễn Minh Đức | Giải Nhất Sáng tạo Kỹ thuật Thành phố Hồ Chí Minh | Sở Khoa học và Công nghệ TP. HCM | 2010 |
10. Phòng thí nghiệm phục vụ nghiên cứu
- Phòng Thí nghiệm Hóa dược
- Phòng Thí nghiệm Sinh học và Dược lý
- Phòng Thí nghiệm Động vật
- Phòng Thí nghiệm Nghiên cứu Liên ngành
- Phòng Thí nghiệm Bào chế - Kiểm nghiệm
- Phòng Thí nghiệm Sản xuất Dược phẩm
11. Một số thiết bị nghiên cứu
