Research Group in Pharmaceutical and Biomedical Sciences

Research Group in Pharmaceutical and Biomedical Sciences

TDTU - 29/03/2025 - 10:40am

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Introduction to the Strong Research Group of the Faculty of Pharmacy

1. General Introduction

The Strong Research Group of the Faculty of Pharmacy, under Ton Duc Thang University (TDTU), is a pioneering unit in the fields of medicinal plant research and development, pharmaceutical technology, quality control, and the application of natural compounds in disease treatment. With a team of experienced scientists and modern facilities, the group is committed to conducting high-value scientific and practical research.

  • Name: Research Group in Pharmaceutical and Biomedical Sciences
  • Abbreviated Name: BIOPHARMED

2. Research Goals and Directions

The group focuses on the following main research directions:

  • Discovery, isolation, and structural elucidation of bioactive natural compounds.

  • Research on formulation technology and improvement of dosage forms to enhance therapeutic effectiveness.

  • Development of analytical methods and quality assessment of medicinal materials and pharmaceutical products.

  • Application of biotechnology in pharmaceutical production.

  • Research and development collaboration with domestic and international institutions.

3. Key Features

  • Leading experts: The group comprises professors, doctors, and dynamic young researchers with extensive expertise across various pharmaceutical fields.

  • Modern equipment: The laboratory is equipped with advanced analytical systems such as LC-MS, GC-MS, and preparative HPLC to support in-depth research in medicinal materials and pharmaceutical technology.

  • High practical application: The group’s research not only contributes academically but also aims for real-world application in the pharmaceutical industry through technology transfer projects.

  • Extensive collaboration: The group maintains cooperative relationships with various universities, research institutes, and pharmaceutical enterprises both domestically and internationally.

 

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4. Research Group Members

The strong research group of the Faculty of Pharmacy brings together highly qualified scientists, including:

Team Leader

Specialization: Medicinal Materials

Email: nguyenminhduc@tdtu.edu.vn

Key Member

Specialization: Analytical Chemistry & Quality Control

Email: nguyentruonghuy@tdtu.edu.vn

Key Member

Specialization: Pharmaceutics – Physical Chemistry of Drugs

Email: lequocviet@tdtu.edu.vn

Key Member

Specialization: Natural Compound Chemistry

Email: nguyenminhhien@tdtu.edu.vn

Key Member

Specialization: Pharmaceutical Biotechnology

Email: lebao@tdtu.edu.vn

Key Member

Specialization: Molecular Medicine

Email: trangiabuu@tdtu.edu.vn

Member

Specialization: Chemistry – Physical Chemistry of Materials

Email: thachutdong@tdtu.edu.vn

Member

Specialization: Biomedical Science

Email: dobichhang@tdtu.edu.vn

Member

Specialization: Medicinal Plants – Traditional Medicine

Email: vuhuynhkimlong@tdtu.edu.vn

Member

Specialization: Physiology – Pathology

Email: lethuyhuong@tdtu.edu.vn

Member

Specialization: Pharmacology, Toxicology, and Clinical Pharmacy

Email: phamductoan@tdtu.edu.vn

Dr. Nguyen Phuong Tram

Member

Specialization: Neuroscience

Email: nguyenphuongtram@tdtu.edu.vn

Dr. Mai Xuan Lan

Member

Specialization: Pharmaceutical Analysis

Email: maixuanlan@tdtu.edu.vn

Với đội ngũ nhân sự chuyên môn cao, giàu kinh nghiệm và chiến lược phát triển bền vững, Nhóm Nghiên cứu Mạnh Khoa Dược hứa hẹn sẽ tiếp tục đóng góp quan trọng vào sự phát triển của ngành dược trong nước và quốc tế.

5. Các công trình công bố

  1. Nguyen HM, Nguyen PK, Le PTA, Nguyen THN, Vu HKL, LeTKC, Anjana Delpe A, Kenneth H.& Daniel R. (2024), Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr, Natural Product Research 17:1-11.

  2. Nguyen HM, Ty VP, Hung QV, Hoai TN, Linh TKN, Bao CN, Khanh L.C. and Duc V.H. (2024) Essential oil from Vietnamese Peperomia leptostachya Hook. & Arn. (Piperaceae): Chemical composition, antioxidant, anti-inflammatory, cytotoxic activities, and in silico analysis, Molecules 29: 2808-2822.
  3. Phan, H. L., Tran, N. C. T., Le, T. H. Y., Le, Q.-V., Le, T.-T.-D., & Thach, U. D. (2024). Fabrication of polydopamine-modified cellulose hydrogel for controlled release of -mangostin. Biopolymers, n/a(n/a), e23613. https://doi.org/https://doi.org/10.1002/bip.23613
  4. Thuy Le H, Vu YT, Duong GH, Le TK, Dang MK, Pham DD, Pham NK, Sichaem J, Nguyen NH, Duong TH. Bio-Guided Isolation of Alpha-Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei. Chem Biodivers. 2024 Jul;21(7):e202400438. doi: 10.1002/cbdv.202400438. Epub 2024 May 28. PMID: 38581153. https://doi.org/10.1002/cbdv.202400438
  5. Nguyen-Thi PT, Vo TK, Le HT, Nguyen NTT, Nguyen TT, Van Vo G. Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders. Pharm Res. 2024 Jun;41(6):1045-1092. doi: 10.1007/s11095-024-03718-x. Epub 2024 Jun 11. PMID: 38862719. https://doi.org/10.1007/s11095-024-03718-x
  6. Tran, G. B., Pham, T. V., Tuan Le, A., Nguyen, N. H., Vo, N. H. H., & Do, B. H. (2024). Chemical composition and the anti-inflammatory effect of volatile compounds from Anaxagorea luzonensis A. Gray. Zeitschrift fur Naturforschung. C, Journal of biosciences, 79(9-10), 329–336. https://doi.org/10.1515/znc-2023-0177
  7. Pham, T. V., Hoang, T. X., Do, B. H., Nguyen, K. T., Nguyen, N. H., & Tran, G. B. (2024). Chemical Compositions, Molecular Docking, Anti-Inflammatory, and Anti-Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam. Chemistry & biodiversity, e202401466. Advance online publication. https://doi.org/10.1002/cbdv.202401466
  8. Nguyen HM, Ty VP, Hung QV, Hoai TN, Linh TKN, Bao CN, Khanh L.C. and Duc V.H. (2024) Essential oil from Vietnamese Peperomia leptostachya Hook. & Arn. (Piperaceae): Chemical composition, antioxidant, anti-inflammatory, cytotoxic activities, and in silico analysis, Molecules 29: 2808-2822.
  9. Le Q.V., Kang S., Lee J., Park H., Sun J.G., Lee J., Shim G. Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection. Biomaterials Research 2024; 28, 0022.
  10. Trinh, Q. D., Mai, H. N., & Pham, D. T. (2024). Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery. Regenerative Therapy, 26, 981-989.
  11. Le, B., Hong, V. T. K., & Yang, S. H. (2024). Anti-Inflammatory Effects of Hydroethanolic Extract from Ehretia asperula on Lipopolysaccharide-Stimulated RAW264. 7 Macrophages. Journal of Microbiology and Biotechnology, 34(6), 1340. https://doi.org/10.4014/jmb.2403.03006
  12. Nguyen HM, Nguyen PK, Le PTA, Nguyen THN, Vu HKL, LeTKC, Anjana Delpe A, Kenneth H.& Daniel R. (2024), Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr, Natural Product Research 17:1-11.
  13. Nguyen PT, Makowiecki K, Lewis TS, Fortune AJ, Clutterbuck M, Reale LA, Taylor BV, Rodger J, Cullen CL and Young KM (2024) Low intensity repetitive transcranial magnetic stimulation enhances remyelination by newborn and surviving oligodendrocytes in the cuprizone model of toxic demyelination. Cell Mol Life Sci 81: 346.  https://doi.org/10.1007/s00018-024-05391-0
  14. Stevens N, Ezegbe C, Fuh-Ngwa V, Makowiecki K, Zarghami A, Nguyen PT, Sansom J, Smith K, Laslett LL, Denham M, Cullen CL, Barnett MH, Hinder MR, Breslin M, Young KM and Taylor BV (2024) A phase II trial examining the safety and preliminary efficacy of repetitive transcranial magnetic stimulation (rTMS) for people living with multiple sclerosis. Trials 25: 598.  https://doi.org/10.1186/s13063-024-08425-x
  15. Nguyen PT, Zarghami A, Makowiecki K, Stevens N, Ezegbe C, Kyle K, Wang C, Ly L, De La Rue K, Hinder MR, Johnson L, Rodger J, Cooper S, Cullen CL, Barnett M, Young KM and Taylor BV (2024) Low-intensity repetitive transcranial magnetic stimulation is safe and well tolerated by people living with MS - outcomes of the phase I randomised controlled trial (TAURUS). Mult Scler J Exp Transl Clin 10: 20552173241252571.  https://doi.org/10.1177/20552173241252571
  16. Park, J1; Le Q.V.1; Wu, Y.; Lee, J.; Oh, Y.K. Tolerogenic nanovaccine for prevention and treatment of autoimmune encephalomyelitis. Advanced Materials, 2023, 35, 2202670. (1 co-first authors).
  17. Wu, Y., Park, J., Jin, D.; Lee, J.; Le, Q.V.*; Oh, Y.K*. Tannic Acid‐Based Nanomaterials for Tolerogenic Immunotherapy of Rheumatoid Arthritis. Advanced Functional Materials 2023; 46, 2305563 (*Co-corresponding authors).
  18. Visarut B, Sornkanok V, Kittipong S, Asma B., Nguyen AB, Thach UD, Do BH, Van SD, Kiep MD, Nguyen HM (2023) Antioxidant, Anti-skin aging, Anti-inflammatory, and Anti- acetylcholinesterase activities of Rourea oligophlebia extracts, Chemistry and Biodiversity 20: e202201096
  19. Nguyen, H. T., Phan, L. K., Huynh, K. L. V., Duong, T. H., Le, H. T., Hai-Yen, N. T., ... & Nguyen, M. D. (2023). Untargeted Metabolomics Approach for the Differentiation between Panax vietnamensis var. vietnamensis and Panax vietnamensis var. fuscidiscus. Metabolites, 13(6), 763.
  20. Visarut B, Sornkanok V, Kittipong S, Asma B., Nguyen AB, Thach UD, Do BH, Van SD, Kiep MD, Nguyen HM (2023) Antioxidant, Anti-skin aging, Anti-inflammatory, and Anti- acetylcholinesterase activities of Rourea oligophlebia extracts, Chemistry and Biodiversity 20: e202201096
  21. Do, M. H., Van Thi Khuat, K., Huynh, P. T., Nguyen, L. N. T., Do, B. H., Pham, P. D., Nguyen, H. D., Nguyen, H. M., & Thach, U. D. (2023). Synthesis, characterization, and antibacterial activity of amino-functionalized microcrystalline cellulose derivatives from cotton fibers. Biomass Conversion and Biorefinery, 13(12), 10595-10603. https://doi.org/10.1007/s13399-022-02391-7 
  22. Nguyen NH, Duong TH, Truong Nguyen H, Vu YT, Tran TM, Ho TT, Mai CC, Mai DT, Nguyen HC, Thuy Le H, Pham DD. New Halogenated Flavonoids from Adenosma bracteosum and Vitex negundo and Their α-Glucosidase Inhibition. Chem Biodivers. 2023 Jul;20(7):e202300390. doi: 10.1002/cbdv.202300390. Epub 2023 Jun 28. PMID: 37293748. https://doi.org/10.1002/cbdv.202300390
  23. Thuy Le H, Vu TY, Nguyen TV, Dinh Tri M, Pham NK, Truong Nguyen H, Nguyen NH, Nguyen HH, Duong TH. A New Carvotacetone Derivative from the Aerial Part of Sphaeranthus africanus. Chem Biodivers. 2023 Jun;20(6):e202300319. doi: 10.1002/cbdv.202300319. Epub 2023 May 30. PMID: 37183173. https://doi.org/10.1002/cbdv.202300319
  24. Nguyen, H. T., Phan, L. K., Huynh, K. L. V., Duong, T. H., Le, H. T., Hai-Yen, N. T., ... & Nguyen, M. D. (2023). Untargeted Metabolomics Approach for the Differentiation between Panax vietnamensis var. vietnamensis and Panax vietnamensis var. fuscidiscus. Metabolites, 13(6), 763.
  25. Tran, G. B., Ding, J., Ye, B., Liu, M., Yu, Y., Zha, Y., Dong, Z., Liu, K., Sudarshan, S., & Ding, H. F. (2023). Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma. Cancer research, 83(13), 2248–2261. https://doi.org/10.1158/0008-5472.CAN-22-3450
  26. Makowiecki K, Stevens N, Cullen CL, Zarghami A, Nguyen PT, Johnson L, Rodger J, Hinder MR, Barnett M, Young KM and Taylor BV (2022) Safety of low-intensity repetitive transcranial magneTic brAin stimUlation foR people living with mUltiple Sclerosis (TAURUS): study protocol for a randomised controlled trial. Trials 23: 626. https://doi.org/10.1186/s13063-022-06526-z
  27. Pham, N. K. T., Nguyen, H. T., Dao, T. B. N., Vu-Huynh, K. L., Nguyen, T. Q. T., Huynh, B. L. C., ... & Duong, T. H. (2022). Two new phenolic compounds from the lichen Parmotrema cristiferum growing in Vietnam. Natural Product Research, 36(15), 3865-3871.
  28. Visarut B, Khwanlada K, Sornkanok V, Asma B, Kittipong S, Thien-Y. V, Kim LV H, Bao L, Huy TN, Kiep MD, Van SD, Nguyen HM (2022) Some antioxidant properties of components from the flower of Ochna integerrima and their beneficial effects on HaCaT keratinocytes and in silico analysis on tyrosinase, Chemistry and Biodiversity 19: e202100882.
  29. Lee HJ, Min HY, Yong YS, Ann J, Nguyen CT, La MT, Hyun SY, Le HT, Kim H, Kwon H, Nam G, Park HJ, Lee J, Lee HY. A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects. Theranostics. 2022 Jan 1;12(1):105-125. doi: 10.7150/thno.63788. PMID: 34987637; PMCID: PMC8690924. https://doi.org/10.7150/thno.63788
  30. Le, B., Do, D. T., Nguyen, H. M., Do, B. H., & Le, H. T. (2022). Preparation, characterization, and anti-adhesive activity of Sulfate polysaccharide from Caulerpa lentillifera against Helicobacter pylori. Polymers, 14(22), 4993. https://doi.org/10.3390/polym14224993
  31. Le, B., Kim, D. G., Phuoc, N. N., Linh, N. T. H., & Yang, S. H. (2022). Dietary supplementation with Pediococcus pentosaceus enhances the innate immune response in and promotes growth of Litopenaeus vannamei shrimp. Journal of Fish Diseases, 45(9), 1343-1354. https://doi.org/10.1111/jfd.13666
  32. Pham, N. K. T., Nguyen, H. T., Dao, T. B. N., Vu-Huynh, K. L., Nguyen, T. Q. T., Huynh, B. L. C., ... & Duong, T. H. (2022). Two new phenolic compounds from the lichen Parmotrema cristiferum growing in Vietnam. Natural Product Research, 36(15), 3865-3871.
  33. Visarut B, Khwanlada K, Sornkanok V, Asma B, Kittipong S, Thien-Y. V, Kim LV H, Bao L, Huy TN, Kiep MD, Van SD, Nguyen HM (2022) Some antioxidant properties of components from the flower of Ochna integerrima and their beneficial effects on HaCaT keratinocytes and in silico analysis on tyrosinase, Chemistry and Biodiversity 19: e202100882.
  34. Lee, J.; Kim, D.; Le, Q.V.*; Oh, Y.K*. Nanotherapeutics for immune network modulation in tumor microenvironments. Semin Cancer Biol. 2022, 86, 1066 - 1087 (*Co-corresponding authors).
  35. Lee, J1; Le, Q.V.1; Ko, SB1 et al. Blood-declustering excretable metal clusters assembled in DNA matrix . Biomaterials 289, 2022, 121754. (1 co-first authors).
  36.  Le Q.V., Lee J, Ko S, Kim H, Vu TY, Choe YS, Oh YK, Shim G. Enzyme-responsive macrocyclic metal complexes for biomedical imaging. Bioeng Transl Med. 2022 Dec 21;8(5):e10478
  37. Nguyen, H. T., Vuong Bui, N. T., Kanhounnon, W. G., Vu Huynh, K. L., Nguyen, T.-V.-A., Nguyen, H. M., Do, M. H., Badawi, M., & Thach, U. D. (2021). Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation [10.1039/D1RA05505D]. RSC Advances, 11(54), 34281-34290. https://doi.org/10.1039/D1RA05505D 
  38. Thach, U. D., Nguyen Thi, H. H., Pham, T. D., Mai, H. D., & Nhu-Trang, T.-T. (2021). Synergetic Effect of Dual Functional Monomers in Molecularly Imprinted Polymer Preparation for Selective Solid Phase Extraction of Ciprofloxacin. Polymers, 13(16), 2788. https://www.mdpi.com/2073-4360/13/16/2788 
  39. Nguyen, H. T., Vu-Huynh, K. L., Nguyen, H. M., Le, H. T., Le, T. H. V., Park, J. H., & Nguyen, M. D. (2021). Evaluation of the saponin content in Panax Vietnamensis acclimatized to lam dong province by HPLC–UV/CAD. Molecules, 26(17), 5373.
  40. Le HT, Lee HJ, Cho J, Min HY, Lee JS, Lee SJ, Lee HY. Insulin-Like Growth Factor Binding Protein-3 Exerts Its Anti-Metastatic Effect in Aerodigestive Tract Cancers by Disrupting the Protein Stability of Vimentin. Cancers (Basel). 2021 Mar 2;13(5):1041. doi: 10.3390/cancers13051041. PMID: 33801272; PMCID: PMC7958122. https://doi.org/10.3390/cancers13051041
  41. Le, B., Anh, P. T. N., & Yang, S. H. (2021). Polysaccharide derived from Nelumbo nucifera lotus plumule shows potential prebiotic activity and ameliorates insulin resistance in HepG2 cells. Polymers, 13(11), 1780. https://doi.org/10.3390/polym13111780
  42. Pham, T. N. A., Le, B., & Yang, S. H. (2021). Anticancer activity of the potential Pyropia yezoensis galactan fractionated in human prostate cancer cells. Biotechnology and Bioprocess Engineering, 26(1), 63-70. https://doi.org/10.1007/s12257-020-0157-8
  43. Nguyen, H. T., Vu-Huynh, K. L., Nguyen, H. M., Le, H. T., Le, T. H. V., Park, J. H., & Nguyen, M. D. (2021). Evaluation of the saponin content in Panax Vietnamensis acclimatized to lam dong province by HPLC–UV/CAD. Molecules, 26(17), 5373.
  44. Le, Q.V.1; Lee, J.1; Lee, H.; Shim, G.; Oh, Y.K. Cell membrane-derived vesicles for delivery of therapeutic agents. Acta Pharm. Sin. B 2021, 11, 2096-2113. (1 co-first authors).
  45. Le, Q.V., Kim, D., Lee, J., Shim, G.; Oh, Y.-K. Photosensitizer-Free Phototherapy with Peptide Micelle Nanoadjuvants for Cancer Vaccine against Metastasis of Melanoma. Adv. Therap. 2021, 4, 2000288.
  46.  Park, J.; Choi, J.; Kim, D.D.; Lee, S.; Lee, B.; Lee, Y.; Kim, S.; Kwon, S.; Noh, M.; Lee, M.O.; Le, Q.V.*; Oh, Y.K*. Bioactive Lipids and Their Derivatives in Biomedical Applications. Biomol. Ther. (Seoul) 2021, 29, 465 - 482. (*Co-corresponding authors).
  47. Le, Q.V.1; Lee, J.; Byun, J.; Shim, G.; Oh, Y.K. DNA-based artificial dendritic cells for in situ cytotoxic T cell stimulation and immunotherapy. Bioact Mater. 2021; 15, 160-172.
  48. Chi Thanh Ma, Eunji Cho, Huy Truong Nguyen, Bo Wu, Thi Hong Van Le, Ki Bong Oh, Sung Won Kwon, Minh Duc Nguyen, Jeong Hill Park, Malacinones A and B, two novel sesquiterpenoids with 6/6/5 tricyclic ring system from the agarwood of Tetrahedron Letter, Vol. 61 (1), 2 Jan 2020, 151355. IF: 2.33.
  49. Vu-Huynh, K. L., Nguyen, H. T., Van Le, T. H., Ma, C. T., Lee, G. J., Kwon, S. W., ... & Nguyen, M. D. (2020). Accumulation of saponins in underground parts of Panax vietnamensis at different ages analyzed by HPLC-UV/ELSD. Molecules, 25(13), 3086.
  50. Vu-Huynh, K. L., Truong, B. V., Bui, V. H., Thanh, H. N. T., & Dang, V. S. (2020, November). Vaccinium chlaenophyllum (Ericaceae), a new species from the Central Highlands of Vietnam. In Annales Botanici Fennici (Vol. 58, No. 1-3, pp. 15-18). Finnish Zoological and Botanical Publishing Board.
  51. Le, B., Ngoc, A. P. T., & Yang, S. H. (2020). Synbiotic fermented soymilk with Weissella cibaria FB069 and xylooligosaccharides prevents proliferation in human colon cancer cells. Journal of applied microbiology, 128(5), 1486-1496. https://doi.org/10.3390/foods9020181
  52. Le, B., Anh, P. T. N., & Yang, S. H. (2020). Enhancement of the anti-inflammatory effect of mustard kimchi on RAW 264.7 macrophages by the Lactobacillus plantarum fermentation-mediated generation of phenolic compound derivatives. Foods, 9(2), 181.
  53. Vu-Huynh, K. L., Nguyen, H. T., Van Le, T. H., Ma, C. T., Lee, G. J., Kwon, S. W., ... & Nguyen, M. D. (2020). Accumulation of saponins in underground parts of Panax vietnamensis at different ages analyzed by HPLC-UV/ELSD. Molecules, 25(13), 3086.
  54. Le, B., Pham, T. N. A., & Yang, S. H. (2020). Prebiotic potential and anti-inflammatory activity of soluble polysaccharides obtained from soybean residue. Foods, 9(12), 1808. https://doi.org/10.3390/foods9121808
  55. Mai, H. N., Pham, D. T., Chung, Y. H., Sharma, N., Cheong, J. H., Yun, J., ... & Kim, H. C. (2020). Glutathione peroxidase-1 knockout potentiates behavioral sensitization induced by cocaine in mice via σ-1 receptor-mediated ERK signaling: A comparison with the case of glutathione peroxidase-1 overexpressing transgenic mice. Brain Research Bulletin, 164, 107-120.
  56. Vu-Huynh, K. L., Truong, B. V., Bui, V. H., Thanh, H. N. T., & Dang, V. S. (2020, November). Vaccinium chlaenophyllum (Ericaceae), a new species from the Central Highlands of Vietnam. In Annales Botanici Fennici (Vol. 58, No. 1-3, pp. 15-18). Finnish Zoological and Botanical Publishing Board.
  57. Yang, H.1; Le, Q.V.1; Shim, G.; Oh, Y. K.; Shin, Y. K. Molecular Engineering of Antibodies for Site-Specific Conjugation to Lipid Polydopamine Hybrid Nanoparticles. Acta Pharm. Sin. B 2020,10, 2212-2226. (1 co-first authors)
  58. Shim, G.; Ko S., Park, J.Y.; Suh, J.H., Le, Q.V., Kim, D.Y., Kim YB, Im, G.H., Kim, H.N.; Choe, Y.S.; Cho. J.; Kim, S.; Oh, Y.K. Tannic acid-functionalized boron nitride nanosheets for theranostics. J. Control. Release 2020, 327, 616-626.
  59. Kim, D.1; Le, Q.V.1; Wu, Y.; Park, J.; Oh, Y.K. Nanovesicle-Mediated Delivery Systems for CRISPR/Cas Genome Editing. Pharmaceutics 2020, 12, 1233. (1 co-first authors).
  60. Xuan-Hao Bui, Phu Hoang Dang, Tuan Trong Vo, Nhi Y Thi Nguyen, Minh Duc Nguyen & Quan Le Tran, “A new cardenolide glycoside from the roots of Streptocaulon juventas (Lour.) Merr. – (Asclepiadaceae)”, Natural Products Research, June 30, 2019. IF: 1.999.
  61. Dahae Lee, Hemin Lee, Kim Long Vu-Huynh, Thi Hong Van Le, Thi Hong Tuoi Do, Gwi Seo Hwang, Joeng Hill Park, Ki Sung Kang, Minh Duc Nguyen and Noriko Yamabe, “Protective effects of panaxynol isolated from Panax vietnamensis agaisnt ciplatin-induced renal damage: In vitro and in vivo studies”, Biomolecules, 2019, 9(12), 890; IF: 4.694.
  62. Vu-Huynh, K. L., Le, T. H. V., Nguyen, H. T., Kim, H. M., Kang, K. S., Park, J. H., & Nguyen, M. D. (2019). Increase in protective effect of Panax vietnamensis by heat processing on cisplatin-induced kidney cell toxicity. Molecules, 24(24), 4627.
  63. Lee, D., Lee, J., Vu-Huynh, K. L., Van Le, T. H., Tuoi Do, T. H., Hwang, G. S., ... & Yamabe, N. (2019). Protective effect of panaxynol isolated from Panax vietnamensis against cisplatin-induced renal damage: in vitro and in vivo studies. Biomolecules, 9(12), 890.
  64. Vu-Huynh, K. L., Le, T. H. V., Nguyen, H. T., Kim, H. M., Kang, K. S., Park, J. H., & Nguyen, M. D. (2019). Increase in protective effect of Panax vietnamensis by heat processing on cisplatin-induced kidney cell toxicity. Molecules, 24(24), 4627.
  65. Lee, D., Lee, J., Vu-Huynh, K. L., Van Le, T. H., Tuoi Do, T. H., Hwang, G. S., ... & Yamabe, N. (2019). Protective effect of panaxynol isolated from Panax vietnamensis against cisplatin-induced renal damage: in vitro and in vivo studies. Biomolecules, 9(12), 890.
  66. Pham, D. T., Chung, Y. H., Mai, H. N., Sharma, N., Yun, J., Kim, H. J., ... & Kim, H. C. (2019). Glutathione peroxidase‐1 gene rescues cocaine‐induced conditioned place preference in mice by inhibiting σ‐1 receptor expression. Clinical and Experimental Pharmacology and Physiology, 46(9), 791-797.
  67. Le, Q.V.; Suh, J.; Oh, Y.K. Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy. AAPS J. 2019, 21, 64.
  68. Shim, G.; Le, Q.V.; Suh, J.; Choi, S.; Kim, G.; Choi, H. G.; Kim, Y. B.; Macgregor, R. B.; Oh, Y. K. Sequential Activation of Anticancer Therapy Triggered by Tumor Microenvironment-Selective Imaging. J. Control. Release 2019, 298, 110–119.
  69. Kim, D.; Le, Q.V.; Kim, Y.B.; Oh, Y.K. Safety and Photochemotherapeutic Application of Poly(γ-Glutamic Acid)-Based Biopolymeric Nanoparticle. Acta Pharm. Sin. B 2019, 9, 565-574.
  70.  Le, Q.V.; Suh, J.; Choi, J. J.; Park, G. T.; Lee, J. W.; Shim, G.; Oh, Y.K. In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence. ACS Nano 2019, 13, 7442–7462.
  71. Lee, J.1; Le, Q. V.1; Yang, G.; Oh, Y. K. Cas9-Edited Immune Checkpoint Blockade PD-1 DNA Polyaptamer Hydrogel for Cancer Immunotherapy. Biomaterials 2019, 218, 119359. (1 co-first authors).
  72. Choi, J. J.1; Le, Q.V.1; Kim, D.; Kim, Y. B.; Shim, G.; Oh, Y. K. High Molecular Weight Chitosan-Complexed RNA Nanoadjuvant for Effective Cancer Immunotherapy. Pharmaceutics 2019, 11, 1–16. (1 co-first authors).
  73. Nguyen PT, Dang DK, Tran HQ, Shin EJ, Jeong JH, Nah SY, Cho MC, Lee YS, Jang CG and Kim HC (2019) Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors. Chem Biol Interact 305: 134-147.  https://doi.org/10.1016/j.cbi.2019.03.017

 

7. List of Applied S&T Products with Intellectual Property Registration and Technology Transfer

  1. Oh, Yu-Kyoung; Shin, Young Kee; Shim, Gayong; Yang, Hobin; Le, Quoc-Viet. Pharmaceutical composition for treating cancer, containing lipid-photothermal nanoparticle having antibody bound to surface, WIPO, 2021, Patent No. WO/2021/201451.
  2. Benedicte Prelot, Peter Hesemann, Ut Dong Thach, and Jerzy Zajac, Organosilicon material for the decontamination of water (2020), United States Patent, US10799850B2.
  3. Nguyen Minh Duc, Jeong Hill Park, Sung Won Kwon, Gwang Jin Lee, Nguyen Truong Huy, Le Thi Hong Van, Vu Huynh Kim Long, Quantification process of main saponins in Vietnamese ginseng (2019), Utility solution, VN-0002205.

8. List of Book Chapters, Materials, Books, and Textbooks Compiled in the Last 5 Years

  1. Shim, G.; Kim. D.; Le, Q.V.; Byun, J.; Park, J.; Oh, Y.K. “8 - Biomaterials for gene editing therapeutics”. In *Biomaterials for Cancer Therapeutics* (Second Edition), edited by Park, K. Woodhead Publishing, 2020, pp. 187–231.
  2. Nguyen Minh Duc, Truong Cong Tri. *Nano Particles – Formulation Techniques, Analysis, Properties & Applications in Pharmacy*, Ho Chi Minh City Medical Publishing House, 2020.
  3. Nguyen Minh Duc, *High-Performance Liquid Chromatography and Its Applications in Research, Drug Testing, and Natural Compound Analysis*, Ho Chi Minh City Medical Publishing House, 2006.
  4. Nguyen Minh Duc, Ryoji Kasai, Kazuhiro Ohtani, Aiko Ito, Kazuo Yamasaki, Nguyen Thoi Nham & Osamu Tanaka, *New Saponins from Vietnamese Ginseng: Highlights on Biogenesis of Dammarane Triterpenoids*. In: Waller, G.R., Yamasaki, K. (eds) *Saponins Used in Traditional and Modern Medicine*. *Advances in Experimental Medicine and Biology*, vol 404. Springer, Boston, MA.
  5. Ton Nu Lien Huong, Nguyen Minh Hien, *Techniques for Extracting Natural Compounds*, Can Tho University Publishing House, 2024.

9. S&T Awards in the Last 5 Years

Title of Work Author Award Name Awarding Organization Year
Research on formulation and effect testing of DR capsules reducing blood uric acid levels from *Phyllanthus amarus* and *Orthosiphon aristatus* Nguyen Minh Duc Third Prize – 26th Ho Chi Minh City Technical Innovation Contest (2019–2020) Department of Science and Technology of Ho Chi Minh City 2019

9. Facilities

No.

Equipment Name

Purpose of Use

Ownership (unit, group, individual?)

Managing Unit

1

HPLC-DAD-MS System

Qualitative and quantitative analysis of natural compounds and pharmaceuticals

Ton Duc Thang University

Faculty of Pharmacy

2

GC-MS System

Qualitative and quantitative analysis of natural compounds and pharmaceuticals

Ton Duc Thang University

Faculty of Pharmacy
3

Preparative-HPLC System

Isolation and purification of reference substances from medicinal plants

Prof. Dr. Nguyen Minh Duc

Faculty of Pharmacy
4

Inverted Fluorescence Microscope

Advanced imaging solutions for various applications to observe cell conditions and expression characteristics

Ton Duc Thang University

Faculty of Pharmacy
5

Realtime PCR System

Gene expression analysis, mutation detection, pathogen detection and quantification, GMO detection, allergen detection, bacterial degradation monitoring, species identification, and parasite health assessment

Ton Duc Thang University

Faculty of Pharmacy
6

ELISA Reader

Evaluation of various biochemical and biological processes in a high-throughput format

Ton Duc Thang University

Faculty of Pharmacy
7

Cell Flow Cytometry

Applications in immunology, molecular biology, bacteriology, virology, cancer biology, and infectious disease monitoring

Ton Duc Thang University

Faculty of Pharmacy